Cheng Man, Zhou Yun, Wang Bin, Mu Ge, Ma Jixuan, Zhou Min, Wang Dongming, Yang Meng, Cao Limin, Xie Li, Wang Xing, Nie Xiuquan, Yu LingLing, Yuan Jing, Chen Weihong
Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Key Laboratory of Environment and Health, Ministry of Education and Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
J Hazard Mater. 2021 Jan 5;401:123278. doi: 10.1016/j.jhazmat.2020.123278. Epub 2020 Jun 23.
Previous studies found that exposure to polycyclic aromatic hydrocarbons (PAHs) was associated with type 2 diabetes (T2D) prevalence. However, the potential mechanism is still unclear. In this study, we investigated 3031 Chinese urban adults to discover the relationship between PAH exposure and plasma Interleukin-22 (IL-22) and potential role of IL-22 in the association between PAH and fasting plasma glucose (FPG) or risk of T2D. After adjustment for potential confounders, significant dose-response relationships were observed between several urinary PAH metabolites with FPG and the prevalence of T2D. Each 1-U increase in ln-transformed value of 2-hydroxynaphthalene (2-OHNa), 2-hydroxyphenanthrene (2-OHPh), 3-hydroxyphenanthrene (3-OHPh), 4-hydroxyphenanthrene (4-OHPh), 9-hydroxyphenanthrene (9-OHPh), 1-hydroxypyrene (1-OHP) or total PAH metabolites was significantly associated with a 0.053, 0.026, 0.037, 0.045, 0.051, 0.041 or 0.047 unit decrease in IL-22 level, respectively. In addition, plasma IL-22 level was negatively associated with FPG and prevalence of T2D in a dose-dependent manner. Mediation analysis showed that IL-22 mediated 8.48 %, 3.87 %, 6.64 %, 6.47 %, and 8.67 % of the associations between urinary 2-OHNa, 1-OHPh, 3-OHPh, 4-OHPh, and 9-OHPh with the prevalence of T2D, respectively. These results indicated that urinary PAHs metabolites were inversely associated with plasma levels of IL-22, but positively related to FPG and the T2D prevalence. Downregulation of IL-22 might play a significant role in mediating PAHs exposure-associated risk increasement of T2D.
以往研究发现，接触多环芳烃（PAHs）与2型糖尿病（T2D）患病率相关。然而，其潜在机制仍不清楚。在本研究中，我们调查了3031名中国城市成年人，以发现PAH暴露与血浆白细胞介素-22（IL-22）之间的关系，以及IL-22在PAH与空腹血糖（FPG）或T2D风险关联中的潜在作用。在对潜在混杂因素进行校正后，观察到几种尿PAH代谢物与FPG和T2D患病率之间存在显著的剂量反应关系。2-羟基萘（2-OHNa）、2-羟基菲（2-OHPh）、3-羟基菲（3-OHPh）、4-羟基菲（4-OHPh）、9-羟基菲（9-OHPh）、1-羟基芘（1-OHP）或总PAH代谢物的自然对数转换值每增加1个单位，分别与IL-22水平降低0.053、0.026、0.037、0.045、0.051、0.041或0.047个单位显著相关。此外，血浆IL-22水平与FPG和T2D患病率呈剂量依赖性负相关。中介分析表明，IL-22分别介导了尿2-OHNa、1-OHPh、3-OHPh、4-OHPh和9-OHPh与T2D患病率之间8.48%、3.87%、6.64%、6.47%和8.67%的关联。这些结果表明，尿PAHs代谢物与血浆IL-22水平呈负相关，但与FPG和T2D患病率呈正相关。IL-22的下调可能在介导PAHs暴露相关的T2D风险增加中起重要作用。
