Stem Cells and Regenerative Medicine Section, University College London Great Ormond Street Institute of Child Health, London, UK.
Department of Pediatric Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
Pediatr Surg Int. 2023 Apr 4;39(1):167. doi: 10.1007/s00383-023-05438-6.
The field of regenerative medicine, encompassing several disciplines including stem cell biology and tissue engineering, continues to advance with the accumulating research on cell manipulation technologies, gene therapy and new materials. Recent progress in preclinical and clinical studies may transcend the boundaries of regenerative medicine from laboratory research towards clinical reality. However, for the ultimate goal to construct bioengineered transplantable organs, a number of issues still need to be addressed. In particular, engineering of elaborate tissues and organs requires a fine combination of different relevant aspects; not only the repopulation of multiple cell phenotypes in an appropriate distribution but also the adjustment of the host environmental factors such as vascularisation, innervation and immunomodulation. The aim of this review article is to provide an overview of the recent discoveries and development in stem cells and tissue engineering, which are inseparably interconnected. The current status of research on tissue stem cells and bioengineering, and the possibilities for application in specific organs relevant to paediatric surgery have been specifically focused and outlined.
再生医学领域涵盖了干细胞生物学和组织工程学等多个学科，随着细胞操作技术、基因治疗和新材料的研究不断积累，该领域正在不断发展。临床前和临床研究的最新进展可能会使再生医学从实验室研究超越界限，走向临床现实。然而，要实现构建生物工程可移植器官的最终目标，仍有许多问题需要解决。特别是，精细组织和器官的工程需要将不同相关方面精细地结合在一起；不仅需要将多种细胞表型以适当的分布重新填充，还需要调整宿主环境因素，如血管生成、神经支配和免疫调节。本文综述的目的是提供对干细胞和组织工程最近发现和发展的概述，这两者是不可分割地相互关联的。本文特别关注和概述了组织干细胞和生物工程的研究现状，以及在儿科手术相关特定器官中的应用可能性。
