Mainali Bigyan B, Yoo James J, Ladd Mitchell R
Department of General Surgery, Atrium Health Wake Forest Baptist, Winston-Salem, NC, USA.
Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC, USA.
Ann Coloproctol. 2024 Aug;40(4):336-349. doi: 10.3393/ac.2024.00437.0062. Epub 2024 Aug 30.
Tissue engineering and regenerative medicine (TERM) is an emerging field that has provided new therapeutic opportunities by delivering innovative solutions. The development of nontraditional therapies for previously unsolvable diseases and conditions has brought hope and excitement to countless individuals globally. Many regenerative medicine therapies have been developed and delivered to patients clinically. The technology platforms developed in regenerative medicine have been expanded to various medical areas; however, their applications in colorectal surgery remain limited. Applying TERM technologies to engineer biological tissue and organ substitutes may address the current therapeutic challenges and overcome some complications in colorectal surgery, such as inflammatory bowel diseases, short bowel syndrome, and diseases of motility and neuromuscular function. This review provides a comprehensive overview of TERM applications in colorectal surgery, highlighting the current state of the art, including preclinical and clinical studies, current challenges, and future perspectives. This article synthesizes the latest findings, providing a valuable resource for clinicians and researchers aiming to integrate TERM into colorectal surgical practice.
组织工程与再生医学（TERM）是一个新兴领域，通过提供创新解决方案带来了新的治疗机会。针对以前无法解决的疾病和病症开发的非传统疗法给全球无数人带来了希望和振奋。许多再生医学疗法已得到开发并临床应用于患者。再生医学中开发的技术平台已扩展到各个医学领域；然而，它们在结直肠手术中的应用仍然有限。应用TERM技术来构建生物组织和器官替代物可能会解决当前的治疗挑战，并克服结直肠手术中的一些并发症，如炎症性肠病、短肠综合征以及运动和神经肌肉功能疾病。本综述全面概述了TERM在结直肠手术中的应用，突出了当前的技术水平，包括临床前和临床研究、当前挑战以及未来展望。本文综合了最新研究结果，为旨在将TERM融入结直肠手术实践的临床医生和研究人员提供了宝贵资源。
