Key Laboratory of Marine Chemistry Theory and Technology (Ocean University of China), Ministry of Education, Qingdao 266100, China.
Department of Spinal Surgery, The Affiliated Hospital of Qingdao University, No. 59 Haier Road, Qingdao, 266000, P. R. China.
J Mater Chem B. 2023 May 3;11(17):3808-3815. doi: 10.1039/d3tb00340j.
Treatment of large gaps in peripheral nerves is a major clinical challenge. Artificial nerve guidance conduits (NGCs) have provided new opportunities for guiding nerve regeneration. In this study, multifunctional black phosphorus (BP) hydrogel NGCs loaded with neuregulin 1 (Nrg1) were fabricated to support peripheral-nerve regeneration: they exhibited good flexibility and nerve regeneration-related cell induction, promoted Schwann-cell proliferation and accelerated neuron-branch elongation. Nrg1 induced the proliferation and migration of Schwann cells, which had beneficial roles in promoting nerve regeneration. immunofluorescence studies revealed BP hydrogel NGCs loaded with Nrg1 promoted sciatic-nerve regeneration and axon remyelination. Our method has great potential for promoting treatment of peripheral-nerve injuries.
治疗周围神经大间隙是一项重大的临床挑战。人工神经引导导管（NGCs）为引导神经再生提供了新的机会。在这项研究中，制备了负载神经调节蛋白 1（Nrg1）的多功能黑磷（BP）水凝胶 NGC 以支持周围神经再生：它们表现出良好的柔韧性和与神经再生相关的细胞诱导作用，促进施万细胞增殖并加速神经元分支伸长。Nrg1 诱导施万细胞的增殖和迁移，这对促进神经再生有有益作用。免疫荧光研究表明，负载 Nrg1 的 BP 水凝胶 NGC 促进坐骨神经再生和轴突髓鞘再生。我们的方法在促进周围神经损伤治疗方面具有巨大的潜力。
