Department of Psychology, Northwestern University, Evanston, IL 60208, USA; Department of Neurobiology and Behavior, University of California at Irvine, Irvine, CA 92697, USA; Center for Neurobiology of Learning and Memory, University of California at Irvine, Irvine, CA 92697, USA.
Department of Psychology, Northwestern University, Evanston, IL 60208, USA.
Cell Rep. 2023 Apr 25;42(4):112331. doi: 10.1016/j.celrep.2023.112331. Epub 2023 Apr 3.
New memories are not quarantined from each other when first encoded; rather, they are interlinked with memories that were encoded in temporal proximity or that share semantic features. By selectively biasing memory processing during sleep, here we test whether context influences sleep consolidation. Participants first formed 18 idiosyncratic narratives, each linking four objects together. Before sleep, they also memorized an on-screen position for each object. During sleep, 12 object-specific sounds were unobtrusively presented, thereby cuing the corresponding spatial memories and impacting spatial recall as a function of initial memory strength. As hypothesized, we find that recall for non-cued objects contextually linked with cued objects also changed. Post-cue electrophysiological responses suggest that activity in the sigma band supports context reinstatement and predicts context-related memory benefits. Concurrently, context-specific electrophysiological activity patterns emerge during sleep. We conclude that reactivation of individual memories during sleep evokes reinstatement of their context, thereby impacting consolidation of associated knowledge.
新记忆在最初编码时彼此不会被隔离；相反，它们与在时间上接近编码的记忆或具有语义特征的记忆相互关联。通过在睡眠期间有选择地偏向记忆处理，我们在这里测试上下文是否会影响睡眠巩固。参与者首先形成了 18 个独特的叙事，每个叙事将四个物体联系在一起。在睡眠前，他们还记住了每个物体在屏幕上的位置。在睡眠过程中，12 个特定于对象的声音被不引人注目地呈现出来，从而提示相应的空间记忆，并根据初始记忆强度影响空间回忆。正如假设的那样，我们发现与提示对象有上下文联系的非提示对象的回忆也发生了变化。后提示的电生理反应表明，西格玛波段的活动支持上下文恢复，并预测与上下文相关的记忆益处。同时，特定于上下文的电生理活动模式在睡眠中出现。我们得出结论，个体记忆在睡眠中的重新激活会引发其上下文的恢复，从而影响相关知识的巩固。
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