Marin Ines, Serrano Manuel, Pietrocola Federico
Institute for Research in Biomedicine (IRB), Barcelona Institute of Science and Technology, 08028, Barcelona, Spain.
Cambridge Institute of Science, Altos Labs, Granta Park, Cambridge, CB21 6GP, UK.
NPJ Aging. 2023 Apr 4;9(1):8. doi: 10.1038/s41514-023-00105-5.
Recent reports in oncological and non-oncological experimental setups provide strong evidence that senescent cells are under the surveillance of CD8 T cell-mediated adaptive immunity. These new data also shed light on the mechanisms that sensitize senescent cells to CD8 T cell-dependent killing, as well as those that enable senescent cells to evade CD8 T cell immunosurveillance. Understanding the interplay between cellular senescence and the adaptive immune system may open new strategies to ameliorate aging and aging-associated diseases.
肿瘤学和非肿瘤学实验设置中的最新报告提供了强有力的证据，表明衰老细胞处于CD8 T细胞介导的适应性免疫监视之下。这些新数据还揭示了使衰老细胞对CD8 T细胞依赖性杀伤敏感的机制，以及使衰老细胞逃避CD8 T细胞免疫监视的机制。了解细胞衰老与适应性免疫系统之间的相互作用可能会开辟改善衰老及衰老相关疾病的新策略。
