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一项对行择期减肥手术的老年患者趋势和结局的 5 年特征描述。

A 5-year characterization of trends and outcomes in elderly patients undergoing elective bariatric surgery.

机构信息

Department of Surgery, Walter C. Mackenzie Health Sciences Centre, University of Alberta, Dvorkin Lounge Mailroom 2G2, 8440 - 112 ST NW, Edmonton, AB, T6G 2B7, Canada.

Department of Surgery, University of Alberta, Edmonton, AB, Canada.

出版信息

Surg Endosc. 2023 Jul;37(7):5397-5404. doi: 10.1007/s00464-023-10029-6. Epub 2023 Apr 4.

Abstract

BACKGROUND

The North American population with severe obesity is aging and with that so will the number of elderly patients (≥ 65 years) meeting indications for metabolic surgery. Trends in bariatric delivery in this population are poorly characterized and outcomes remain conflicting, limiting potential uptake and delivery.

METHODS

The MBSAQIP database was used to identify elderly patients (≥ 65 years) undergoing elective bariatric surgery from 2015 to 2019. Our objectives were to analyze their unique characteristics, surgical operative trends, and outcomes by comparing to a non-elderly cohort. Multivariable logistic regression identified independent predictors of serious complications and 30-day mortality.

RESULTS

There was a total of 751,607 patients, 5.3% (n = 39,854) were elderly. Mean ages were 43 ± 11 years (non-elderly) versus 68 ± 3 years (elderly). Elderly patients were less likely to be female (70.7% elderly; 80.1% non-elderly) and had lower BMI (43.17 ± 6.64 kg/m elderly; 45.42 ± 7.87 kg/m non-elderly). They had higher American Society of Anesthesiologists classification, lower functional status, more insulin dependent diabetes, and hypertension, among other comorbidities. There were no clinically significant differences between the most frequently performed bariatric surgery. Sleeve gastrectomy remained the most common (73.7% non-elderly; 72.3% elderly); however, operative time was longer among the elderly. Functional status was most predictive for both serious complications (OR 1.72; CI 1.53-1.94) and mortality (OR 2.92; CI 1.98-4.31). Surgery among elderly patients was associated with poorer 30-day postoperative outcomes across all categories and was independently associated with serious complications (OR 1.23; CI 1.17-1.30, p < 0.001; AR 4.64%) and 30-day mortality (OR 2.49; CI 2.00-3.11, p < 0.001; AR 0.27%), after adjusting for comorbidities.

CONCLUSIONS

After adjusting for comorbidities, functional status remains the most predictive factor for poor outcomes; however, elderly patients have increased 30-day odds of serious complications and 30-day mortality, suggesting a need to tailor our approach to these individuals that carry a unique operative risk.

摘要

背景

北美严重肥胖人群正在老龄化,因此符合代谢手术指征的老年患者(≥ 65 岁)数量也将增加。该人群中减重手术的提供趋势描述不足,结果仍存在争议,限制了潜在的手术量和提供。

方法

使用 MBSAQIP 数据库确定了 2015 年至 2019 年间接受择期减重手术的老年患者(≥ 65 岁)。我们的目标是通过与非老年队列进行比较,分析他们的独特特征、手术操作趋势和结果。多变量逻辑回归确定严重并发症和 30 天死亡率的独立预测因素。

结果

共有 751607 名患者,其中 5.3%(n=39854)为老年患者。平均年龄分别为 43±11 岁(非老年)和 68±3 岁(老年)。老年患者女性比例较低(70.7%为老年患者;80.1%为非老年患者),BMI 也较低(老年患者为 43.17±6.64kg/m;非老年患者为 45.42±7.87kg/m)。他们的美国麻醉医师协会分类较高,功能状态较低,更依赖胰岛素治疗糖尿病和高血压等合并症。最常进行的减重手术之间没有明显的临床差异。袖状胃切除术仍然是最常见的(非老年患者为 73.7%;老年患者为 72.3%);然而,老年患者的手术时间较长。功能状态对严重并发症(OR 1.72;CI 1.53-1.94)和死亡率(OR 2.92;CI 1.98-4.31)都具有最强的预测作用。老年患者的手术与所有类别的术后 30 天结局较差相关,并且与严重并发症(OR 1.23;CI 1.17-1.30,p<0.001;AR 4.64%)和 30 天死亡率(OR 2.49;CI 2.00-3.11,p<0.001;AR 0.27%)独立相关,在调整了合并症后。

结论

在调整了合并症后,功能状态仍然是预测不良结局的最主要因素;然而,老年患者的严重并发症和 30 天死亡率的 30 天几率增加,这表明需要针对这些具有独特手术风险的个体调整我们的方法。

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