慢性乙型肝炎与 HIV 合并感染。
Chronic hepatitis B and HIV coinfection.
机构信息
University of Washington, Seattle, WA, USA.
出版信息
Top Antivir Med. 2023 Mar 31;31(1):14-22.
Abstract
Hepatitis B virus (HBV) infection is common among people with HIV owing to shared modes of viral transmission. Compared with individuals with HBV infection alone, people with HIV/HBV coinfection experience an accelerated progression of liver disease, including increased risks for hepatocellular carcinoma, liver-related mortality, and all-cause mortality. Therefore, HBV screening and appropriate treatment are crucial for people with HIV. This article reviews the epidemiology, natural history, and management of HIV/HBV coinfection, as well as recommendations for prevention of HBV infection among people with HIV.
摘要
乙型肝炎病毒 (HBV) 感染在 HIV 感染者中很常见，因为它们具有共同的病毒传播模式。与单独感染 HBV 的个体相比，HIV/HBV 合并感染的个体肝脏疾病进展更快，包括肝癌、与肝脏相关的死亡率和全因死亡率的风险增加。因此，HBV 筛查和适当的治疗对于 HIV 感染者至关重要。本文综述了 HIV/HBV 合并感染的流行病学、自然史和管理，以及预防 HIV 感染者感染 HBV 的建议。
相似文献
1
Chronic hepatitis B and HIV coinfection.慢性乙型肝炎与 HIV 合并感染。
Top Antivir Med. 2023 Mar 31;31(1):14-22.
2
Differing profiles of people diagnosed with acute and chronic hepatitis B virus infection in British Columbia, Canada.不列颠哥伦比亚省加拿大急性和慢性乙型肝炎病毒感染者的不同特征。
World J Gastroenterol. 2018 Mar 21;24(11):1216-1227. doi: 10.3748/wjg.v24.i11.1216.
3
Triple Threat: HDV, HBV, HIV Coinfection.三重威胁：HDV、HBV、HIV 合并感染。
Clin Liver Dis. 2023 Nov;27(4):955-972. doi: 10.1016/j.cld.2023.05.010. Epub 2023 Jul 1.
4
Management of Chronic Hepatitis B in HIV-Coinfected Patients.慢性乙型肝炎合并 HIV 感染患者的管理。
Viruses. 2022 Sep 13;14(9):2022. doi: 10.3390/v14092022.
5
The epidemiology, natural history and prevention of hepatitis B: implications of HIV coinfection.乙型肝炎的流行病学、自然史及预防：合并感染HIV的影响
Antivir Ther. 2007;12 Suppl 3:H3-13.
6
Hepatitis B Virus-related Care Quality in Patients With Hepatitis B/Human Immunodeficiency Virus Coinfection Versus Hepatitis B Monoinfection: A National Cohort Study.乙型肝炎病毒/人类免疫缺陷病毒合并感染与乙型肝炎单感染患者的乙型肝炎病毒相关护理质量：一项全国性队列研究。
Clin Infect Dis. 2022 Oct 29;75(9):1529-1536. doi: 10.1093/cid/ciac227.
7
Hepatitis B virus coinfection in human immunodeficiency virus-infected patients: a review.人类免疫缺陷病毒感染患者中的乙型肝炎病毒合并感染：综述
World J Gastroenterol. 2014 Oct 28;20(40):14598-614. doi: 10.3748/wjg.v20.i40.14598.
8
HIV-hepatitis B virus coinfection: epidemiology, pathogenesis, and treatment.HIV-乙型肝炎病毒合并感染：流行病学、发病机制和治疗。
AIDS. 2017 Sep 24;31(15):2035-2052. doi: 10.1097/QAD.0000000000001574.
9
Epidemiology, Natural History, and Treatment of Hepatitis Delta Virus Infection in HIV/Hepatitis B Virus Coinfection.HIV/乙型肝炎病毒合并感染中乙型肝炎 delta 病毒感染的流行病学、自然史和治疗。
Curr HIV/AIDS Rep. 2020 Aug;17(4):405-414. doi: 10.1007/s11904-020-00508-z.
10
Changing Epidemiology of Hepatitis B Virus and Hepatitis C Virus Coinfection in a Human Immunodeficiency Virus-Positive Population in China: Results From the Third and Fourth Nationwide Molecular Epidemiologic Surveys.中国人类免疫缺陷病毒阳性人群中乙型肝炎病毒和丙型肝炎病毒合并感染的流行情况变化：来自第三次和第四次全国分子流行病学调查的结果。
Clin Infect Dis. 2021 Aug 16;73(4):642-649. doi: 10.1093/cid/ciab058.
引用本文的文献
1
The Role of Liver Biopsy and Fine Needle Aspiration in Novel HBV Therapeutics in HIV and HBV Coinfection.肝活检和细针穿刺抽吸在HIV与HBV合并感染新型乙肝治疗中的作用
Curr HIV/AIDS Rep. 2025 Sep 15;22(1):45. doi: 10.1007/s11904-025-00754-z.
2
Longitudinal observation of chronic domestic cat hepadnavirus infection in cats with evidence of extrahepatic involvement.对有肝外受累证据的猫慢性猫乙肝病毒感染的纵向观察。
J Feline Med Surg. 2025 Sep;27(9):1098612X251359148. doi: 10.1177/1098612X251359148. Epub 2025 Sep 13.
3
Socioeconomic, Behavioural, and Protective Factors Influences on the Combined Prevention of HIV Infection Among Brazilian Amazon Men Who Have Sex with Men: A Cross-Sectional Study.社会经济、行为和保护因素对巴西亚马逊地区男男性行为者联合预防艾滋病毒感染的影响：一项横断面研究
Trop Med Infect Dis. 2025 Aug 16;10(8):231. doi: 10.3390/tropicalmed10080231.
4
Epidemiological and clinical profile of hepatitis B infection in ART-naïve people living with HIV in Maputo, Mozambique: a cross-sectional study.莫桑比克马普托未接受抗逆转录病毒治疗的HIV感染者中乙型肝炎感染的流行病学和临床特征：一项横断面研究
BMJ Public Health. 2025 Aug 4;3(2):e001563. doi: 10.1136/bmjph-2024-001563. eCollection 2025.
5
Investigation of Hepatitis C, D, and HIV Seroprevalence and Evaluation of APRI and FIB-4 Scores in HbsAg-Positive Patients.乙肝表面抗原阳性患者丙型肝炎、丁型肝炎和艾滋病毒血清流行率调查及APRI和FIB-4评分评估
Viruses. 2025 Apr 15;17(4):568. doi: 10.3390/v17040568.
6
Non-Communicable Diseases in Patients with Human Immunodeficiency Virus and Their Risk Factors.人类免疫缺陷病毒感染者的非传染性疾病及其危险因素
Infect Chemother. 2025 Mar;57(1):131-137. doi: 10.3947/ic.2024.0123.
7
HBV Reactivation in Immunosuppressed Patients: Screening, Prevention, and Management Including Solid Organ Transplant Recipients.免疫抑制患者中的乙肝病毒再激活：筛查、预防及管理，包括实体器官移植受者
Viruses. 2025 Mar 9;17(3):388. doi: 10.3390/v17030388.
8
Enhancing Hepatitis B Virus Vaccine Uptake and Immunity Through Long-Acting Antiretroviral Therapy Programmatic Synergy in the US South.通过长效抗逆转录病毒治疗方案协同作用提高美国南部地区乙型肝炎病毒疫苗接种率和免疫力
Open Forum Infect Dis. 2025 Feb 19;12(3):ofaf096. doi: 10.1093/ofid/ofaf096. eCollection 2025 Mar.
9
The Impact of Antiretroviral Therapy on Liver Function Among Pregnant Women Living with HIV in Co-Existence with and Without Pre-Eclampsia.抗逆转录病毒疗法对合并或未合并子痫前期的感染艾滋病毒孕妇肝功能的影响
Viruses. 2024 Dec 28;17(1):28. doi: 10.3390/v17010028.
10
Prevalence of HDV, HCV, and HIV Infection in the Population of Patients Infected with HBV in a Romanian Cohort.罗马尼亚一个队列中感染乙肝病毒患者群体中丁型肝炎病毒、丙型肝炎病毒和艾滋病毒感染的患病率。
Microorganisms. 2025 Jan 9;13(1):118. doi: 10.3390/microorganisms13010118.
本文引用的文献
1
Universal Hepatitis B Vaccination in Adults Aged 19-59 Years: Updated Recommendations of the Advisory Committee on Immunization Practices - United States, 2022.19至59岁成年人的乙型肝炎普遍疫苗接种：美国免疫实践咨询委员会2022年更新建议
MMWR Morb Mortal Wkly Rep. 2022 Apr 1;71(13):477-483. doi: 10.15585/mmwr.mm7113a1.
2
Serological response with Heplisav-B® in prior Hepatitis B vaccine non-responders living with HIV.在既往对乙型肝炎疫苗无应答的 HIV 感染者中，Heplisav-B®的血清学应答。
Vaccine. 2021 Oct 22;39(44):6529-6534. doi: 10.1016/j.vaccine.2021.09.050. Epub 2021 Sep 30.
3
Risk of HCC With Hepatitis B Viremia Among HIV/HBV-Coinfected Persons in North America.北美 HIV/HBV 共感染人群中乙型肝炎病毒血症与 HCC 风险。
Hepatology. 2021 Sep;74(3):1190-1202. doi: 10.1002/hep.31839. Epub 2021 Jun 22.
4
Brief Report: Heplisav-B Seroprotection in People With HIV: A Single-Center Experience.简要报告：HIV 感染者中 Heplisav-B 的血清保护作用：单中心经验。
J Acquir Immune Defic Syndr. 2021 Apr 1;86(4):445-449. doi: 10.1097/QAI.0000000000002573.
5
Global Burden of Hepatitis B Infection in People Living With Human Immunodeficiency Virus: A Systematic Review and Meta-analysis.全球乙型肝炎病毒感染在人类免疫缺陷病毒感染者中的负担：系统评价和荟萃分析。
Clin Infect Dis. 2020 Dec 31;71(11):2799-2806. doi: 10.1093/cid/ciz1170.
6
Prevalence and burden of HBV co-infection among people living with HIV: A global systematic review and meta-analysis.HBV 合并感染在 HIV 感染者中的流行率和负担：一项全球系统评价和荟萃分析。
J Viral Hepat. 2020 Mar;27(3):294-315. doi: 10.1111/jvh.13217. Epub 2019 Dec 22.
7
Revisiting Hepatitis B Virus: Challenges of Curative Therapies.重新审视乙型肝炎病毒：治愈疗法的挑战。
J Virol. 2019 Sep 30;93(20). doi: 10.1128/JVI.01032-19. Print 2019 Oct 15.
8
Changes in liver stiffness after ART initiation in HIV-infected Nigerian adults with and without chronic HBV.ART 治疗开始后，尼日利亚 HIV 感染成人中有无慢性 HBV 者的肝硬度变化。
J Antimicrob Chemother. 2019 Jul 1;74(7):2003-2008. doi: 10.1093/jac/dkz145.
9
Prevalence of Hepatitis B and Hepatitis D Virus Infections in the United States, 2011-2016.2011-2016 年美国乙型肝炎和丁型肝炎病毒感染的流行情况。
Clin Infect Dis. 2019 Aug 1;69(4):709-712. doi: 10.1093/cid/ciz001.
10
Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance.慢性乙型肝炎的预防、诊断和治疗最新进展：美国肝病研究学会2018年乙型肝炎指南
Hepatology. 2018 Apr;67(4):1560-1599. doi: 10.1002/hep.29800.
Zotero 插件