探索噬菌体疗法治疗耐药菌感染。
Exploring bacteriophage therapy for drug-resistant bacterial infections.
机构信息
University of California San Diego, La Jolla, CA, USA.
出版信息
Top Antivir Med. 2023 Mar 31;31(1):23-30.
The golden age of antibiotics, which lasted from the 1930s until 2005, brought a brisk clip of antibiotic discovery and fueled optimism about the victory of modern medicine over bacterial infections. Since then, however, with a stalled antibiotic discovery effort and wide-spread antibiotic use, antimicrobial resistance has emerged as a major global health threat. Bacteriophages, or phages (literally viruses that infect certain bacteria), have coevolved with bacteria for almost 4 billion years and are the most abundant organisms on the earth. Substantial progress is being made such that selection, engineering, and synthetic production of phages may make it possible for these lethal enemies of bacteria to be harnessed as potent allies in our battle against antimicrobial resistance.
抗生素的黄金时代从 20 世纪 30 年代持续到 2005 年，在此期间抗生素的发现速度很快，人们对现代医学战胜细菌感染充满乐观。然而，自那时以来，由于抗生素发现工作停滞不前和广泛使用抗生素，抗菌药物耐药性已成为一个主要的全球健康威胁。噬菌体，或噬菌体（字面意思是感染某些细菌的病毒），与细菌共同进化了近 40 亿年，是地球上最丰富的生物。目前正在取得实质性进展，使得噬菌体的选择、工程和合成生产可能使这些细菌的致命敌人成为我们对抗抗菌药物耐药性的有力盟友。
Zotero 插件