Zhang Qi-Qi, Hu Kun, Sun Han-Dong, Puno Pema-Tenzin
State Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan, People's Republic of China.
University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
Nat Prod Bioprospect. 2023 Apr 6;13(1):12. doi: 10.1007/s13659-023-00376-1.
Four new 14(13 → 12)-abeolanostane triterpenoids featuring extended π-conjugated systems, kadcoccitanes E-H (1-4), were obtained from the stems of Kadsura coccinea through using a HPLC - UV-guided approach. Their structural and configurational determination was accomplished through extensive spectroscopic analysis coupled with quantum chemical calculations. Kadcoccitanes E-H were tested for their cytotoxic activities against five human tumor cell lines (HL-60, A-549, SMMC-7721, MDA-MB-231, SW-480) but none of them exhibited activities at the concentration 40 μM.
通过高效液相色谱-紫外引导方法，从绯红南五味子茎中获得了四种具有扩展π共轭体系的新的14(13 → 12)-乌苏烷型三萜类化合物，即南五味子烷E-H（1-4）。通过广泛的光谱分析结合量子化学计算完成了它们的结构和构型测定。测试了南五味子烷E-H对五种人类肿瘤细胞系（HL-60、A-549、SMMC-7721、MDA-MB-231、SW-480）的细胞毒性活性，但在40 μM浓度下它们均未表现出活性。
Zotero 插件
