可可西托酮 A 和 B，两种来自于两面针的新的 6/6/5/5-稠合四环三萜。

Kadcoccitones A and B, two new 6/6/5/5-fused tetracyclic triterpenoids from Kadsura coccinea.

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China.

出版信息

Org Lett. 2012 Dec 21;14(24):6362-5. doi: 10.1021/ol303168y. Epub 2012 Dec 11.

DOI:10.1021/ol303168y

PMID:23230829

Abstract

A pair of new triterpenoid epimers, kadcoccitones A (1) and B (2), together with a new biogenetically related compound kadcoccitone C (3), were isolated from Kadsura coccinea. The epimers featured an unprecedented carbon skeleton with a 6/6/5/5-fused tetracyclic ring system unit and a C(9) side chain. Their structures were determined by spectroscopic data, ECD calculation, and single-crystal X-ray diffraction. Compounds 1 and 3 showed anti-HIV-1 activity with an EC(50) value of 47.91 and 32.66 μg/mL, respectively.

摘要

一对新的三萜类差向异构体，考达素酮 A（1）和 B（2），以及一种新的生物相关化合物考达素酮 C（3），从红毛藤中分离得到。这些差向异构体具有前所未有的碳骨架，包括一个 6/6/5/5 稠合的四环环系统单元和一个 C(9)侧链。它们的结构通过光谱数据、ECD 计算和单晶 X 射线衍射确定。化合物 1 和 3 表现出抗 HIV-1 活性，EC(50) 值分别为 47.91 和 32.66 μg/mL。