Brandimarte Bruno, Di Rienzo Businco Lino, Cappello Francesco, Fiore Roberto, Bastone Giuseppe, Gualdi Gianfranco, Sollaku Saadi, Casciani Emanuele, Tortorella Federica, Longo Pasquale, Centanini Eleonora, Pavaci Silva, Sangiuolo Federica, Patrizi Maria Patrizia, Miersch Shane, Sidhu Sachdev S, Sacchini Virgilio, Novelli Giuseppe
Electronic Measurements Physics Department, Sapienza University, Rome, Italy.
Otorhinolaryngology Department, Institute of Sport Medicine, Sport e Salute, Rome, Italy.
Heliyon. 2023 Mar 20;9(3):e14673. doi: 10.1016/j.heliyon.2023.e14673. eCollection 2023 Mar.
The currently available nebulization devices have a slow aerosol flow and produce vapor with large microdrops. Improved devices that achieve higher airflow and produce smaller microdrops are needed to improve the clinical care of patients. To address this critical need, we developed a novel system for the molecular vaporization of liquids. This device vaporizes an active pharmacological substance dissolved in water, alcohol, or a mixture of water and alcohol using two energy sources at the same time: high-frequency ultrasound and thermal induction. Application of energy to a solution contained in the device's tank allows, within tens of seconds, for the vaporization of the solution itself, with the generation of a vapor consisting of microdrops of very small diameter (0.2-0.3 μm). In this article, we illustrate the technology used, the main verification tests performed, and the primary fields of application for this device. In particular, the advantages of both the aerosol delivery system and the administration system are highlighted.
目前可用的雾化装置气溶胶流速缓慢，产生的蒸汽含有大微滴。需要改进的装置来实现更高的气流并产生更小的微滴，以改善患者的临床护理。为满足这一关键需求，我们开发了一种用于液体分子汽化的新型系统。该装置同时使用两种能量源：高频超声和热感应，将溶解在水、酒精或水与酒精混合物中的活性药理物质汽化。对装置储罐中所含溶液施加能量，可在数十秒内使溶液本身汽化，产生由直径非常小（0.2 - 0.3μm）的微滴组成的蒸汽。在本文中，我们阐述了所使用的技术、进行的主要验证测试以及该装置的主要应用领域。特别是，突出了气溶胶输送系统和给药系统的优势。
