Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE 19716, USA.
Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE 19716, USA.
Curr Opin Biotechnol. 2022 Apr;74:104-109. doi: 10.1016/j.copbio.2021.10.017. Epub 2021 Dec 8.
Global implementation of messenger RNA (mRNA) vaccines represents an enormous advance with far-reaching implications for respiratory disease treatment. mRNA vaccines offer exceptional efficacy and versatile capacity to be adapted to new viruses and variants; however, critical questions remain regarding immune persistence and formulation stability. This represents a significant opportunity for developing next-generation, inhaled mRNA vaccines with the ability to drive long-lasting, tissue-specific memory responses needed for rapid recall and immediate local protection. Advances in pulmonary delivery technologies offer potential to overcome translational challenges including design of aerosol-stable and lung-stable formulations, navigation of pulmonary biological barriers, and a lack of predictive models and measurement techniques. We highlight recent advances in each of these challenge areas to illuminate the path to translation.
信使 RNA（mRNA）疫苗的全球应用代表了一个巨大的进步，对呼吸道疾病的治疗具有深远的影响。mRNA 疫苗具有极高的疗效和灵活的适应新病毒和变体的能力；然而，关于免疫持久性和配方稳定性仍存在一些关键问题。这为开发新一代吸入式 mRNA 疫苗提供了重要机会，这些疫苗具有产生持久、组织特异性记忆应答的能力，可快速召回并立即提供局部保护。肺部给药技术的进步为克服转化挑战提供了潜力，包括设计气溶胶稳定和肺部稳定的制剂、穿越肺部生物屏障、缺乏预测模型和测量技术。我们强调了这些挑战领域的最新进展，以阐明转化的途径。
