Garratt Michael, Neyt Christine, Ladyman Sharon R, Pyrski Martina, Zufall Frank, Leinders-Zufall Trese
Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.
Centre for Neuroendocrinology, University of Otago, Dunedin 9016, New Zealand.
iScience. 2023 Mar 20;26(4):106455. doi: 10.1016/j.isci.2023.106455. eCollection 2023 Apr 21.
Olfactory stimuli from food influence energy balance, preparing the body for digestion when food is consumed. Social chemosensory cues predict subsequent energetic changes required for social interactions and could be an additional sensory input influencing energy balance. We show that exposure to female chemostimuli increases metabolic rate in male mice and reduces body weight and adipose tissue expansion when mice are fed a high-fat diet. These responses are linked to detection of female chemostimuli via G-protein Gαo-expressing vomeronasal sensory neurons. Males with Gαo deleted in the olfactory system are fertile but do not show changes in body weight when paired with females and show severely blunted changes in energy expenditure when exposed to female bedding. These results establish that metabolic and reproductive responses to females can be partly uncoupled in male mice and that detection of female chemostimuli is a central regulator of energy metabolism and lipid storage.
来自食物的嗅觉刺激会影响能量平衡，在摄入食物时让身体为消化做好准备。社会化学感应线索预示着社交互动所需的后续能量变化，可能是影响能量平衡的额外感官输入。我们发现，当给雄性小鼠喂食高脂饮食时，暴露于雌性化学刺激物会提高其代谢率，并减少体重和脂肪组织扩张。这些反应与通过表达G蛋白Gαo的犁鼻感觉神经元检测雌性化学刺激物有关。嗅觉系统中Gαo缺失的雄性小鼠具有生育能力，但与雌性小鼠配对时体重没有变化，暴露于雌性垫料时能量消耗的变化也严重减弱。这些结果表明，雄性小鼠对雌性的代谢和生殖反应可能部分解耦，并且检测雌性化学刺激物是能量代谢和脂质储存的核心调节因素。
