Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
J Mol Recognit. 2023 Jul;36(7):e3015. doi: 10.1002/jmr.3015. Epub 2023 May 10.
Recent interest has focused on the biosynthesis of metal nanoparticles (NPs), particularly from plants. The production of precipitate served as an early indicator of the presence in the present study's use of ZnO NPs green synthesis of these particles, which was further validated by; Fourier transform infrared spectroscopy, x-ray diffraction. Additionally, the Brunauer-Emmett-Teller was used to calculate the surface area, which came out to be 119.12 m /g. Since the true effects of new pollutants, including medicines, on the environment and human health are not well understood, their presence in aquatic systems poses a severe hazard. For this reason, the antibiotic Ibuprofen (IBP) was absorbable to ZnO-NPs in this search. As opposed to fitting to Langmuir isothermally, the adsorption process was discovered to be pseudo-second-order kinetically, and the reaction was determined to be a chemisorption process. The process was endothermic and spontaneous, according to thermodynamic studies. Maximizing IBP removal from aqueous solution required the use of a Box-Behnken surface statistical design with four components, four levels, and response surface modeling. Solution pH, IBP concentration, duration, and dose were the four parameters that were utilized. The regeneration process, which is employed for five cycles with excellent efficiency, is the best benefit of using ZnO-NPs. Examine the elimination of pollutants from actual samples as well. However, the adsorbent is quite effective at reducing biological activity. At high concentrations of ZnO-NPs demonstrated notable antioxidant activity and Red Blood Cell (RBC) hemocompatibility and no discernible hemolysis was seen. ZnO-NPs demonstrated a notable percent suppression of α-amylase up to 53.6% at 400 μg/mL, and so displayed potential as an antidiabetic. Cyclooxygenase was suppressed by ZnO-NPs in an anti-inflammatory test (COX-1 & COX-2) up to 56.32% and 52.04% at a concentration of 400 μg/mL, respectively. Significant anti-Alzheimer potential was demonstrated by ZnO-NPs at 400 μg/mL by inhibiting Acetyl cholinesterase and Butyl cholinesterase up to 68.98 ± 1.62% and 62.36%, respectively. We concluded that guava extract is helpful for ZnO-NP reduction and capping. The bioengineered NPs could prevent Alzheimer's, diabetes, and inflammation and were biocompatible.
最近的研究热点集中在金属纳米粒子（NPs）的生物合成上，特别是来自植物的 NPs。在本研究中，沉淀的产生被用作这些粒子的 ZnO NPs 绿色合成的早期指标，这一事实通过傅里叶变换红外光谱、X 射线衍射进一步得到了验证。此外，使用 Brunauer-Emmett-Teller 计算表面积，得出结果为 119.12 m2/g。由于包括药物在内的新型污染物对环境和人类健康的真正影响还没有被很好地理解，它们在水生系统中的存在构成了严重的危害。出于这个原因，在这项研究中，抗生素布洛芬（IBP）被吸附到 ZnO-NPs 上。与 Langmuir 等温线拟合相反，吸附过程被发现是伪二级动力学，反应被确定为化学吸附过程。热力学研究表明，该过程是吸热和自发的。使用四因素、四水平的 Box-Behnken 表面统计设计，使从水溶液中最大程度地去除 IBP。溶液 pH 值、IBP 浓度、时间和剂量是四个被利用的参数。再生过程可在 5 个循环内实现高效率，是使用 ZnO-NPs 的最佳优势。检查实际样品中的污染物去除情况也是如此。然而，吸附剂在降低生物活性方面非常有效。在高浓度的 ZnO-NPs 下，表现出显著的抗氧化活性和红细胞（RBC）血液相容性，并且没有明显的溶血现象。在 400 μg/mL 时，ZnO-NPs 对α-淀粉酶的抑制率高达 53.6%，因此具有作为抗糖尿病药物的潜力。在抗炎试验（COX-1 和 COX-2）中，ZnO-NPs 抑制环氧化酶，在 400 μg/mL 时分别达到 56.32%和 52.04%。在 400 μg/mL 时，ZnO-NPs 对乙酰胆碱酯酶和丁酰胆碱酯酶的抑制率高达 68.98±1.62%和 62.36%，表现出显著的抗阿尔茨海默病潜力。我们得出的结论是，番石榴提取物有助于 ZnO-NP 的还原和封端。生物工程 NPs 可以预防阿尔茨海默病、糖尿病和炎症，并且具有生物相容性。
