Department of Biotechnology, Faculty of Engineering, Karpagam Academy of Higher Education, Coimbatore, India.
Faculty of Pharmacy, Karpagam Academy of Higher Education, Coimbatore, India.
Phytother Res. 2023 May;37(5):2102-2118. doi: 10.1002/ptr.7821. Epub 2023 Apr 6.
Liver problems are a worldwide concern, and conventional medicinal therapies are ineffective. Hence, safeguarding the healthy liver is vital for good health and well-being. Infections due to virus, immune problems, cancer, alcohol abuse, and an overdose of drugs are some of the causes of liver diseases. Antioxidants derived from medicinal plants and conventional dietary sources can protect the liver from damages caused by oxidative stress system and various chemicals. Plants and plant-derived phytochemicals are appealing hepatoprotective agents since they have less side effects and still there is a lot of interest shown in using herbal tonics for treating liver disorders. This review therefore primarily focuses on newly discovered medicinal plants and compounds produced from plants that fall under the classifications of flavonoids, alkaloids, terpenoids, polyphenolics, sterols, anthocyanins, and saponin glycosides, all of which have the potential to be hepatoprotective. Hosta plantaginea, Ligusticum chuanxiong, Daniella oliveri, Garcinia mangostana, Solanum melongena, Vaccinium myrtillus, Picrorhiza kurroa, and Citrus medica are some potential plants having hepatoprotective effects. We conclude that these phytochemicals and the plant extracts listed above are used in the future to treat a variety of liver diseases, additional research is still needed to develop safer and more potent phytochemical drugs.
肝脏问题是一个全球性的关注问题，传统的医学疗法往往无效。因此，保护肝脏健康对于身体健康和幸福至关重要。病毒感染、免疫问题、癌症、酗酒和药物过量等都是肝脏疾病的一些原因。从药用植物和常规饮食来源中提取的抗氧化剂可以保护肝脏免受氧化应激系统和各种化学物质的损伤。植物和植物源性植物化学物质是有吸引力的保肝剂，因为它们的副作用较小，而且人们仍然对使用草药补品治疗肝脏疾病表现出很大的兴趣。因此，本综述主要关注新发现的药用植物和植物中产生的化合物，这些化合物属于黄酮类、生物碱类、萜类、多酚类、甾醇类、花青素类和皂苷糖苷类，它们都具有潜在的保肝作用。玉簪属植物、川芎、Daniella oliveri、藤黄属、茄属、越橘属、苦玄参属和芸香科植物等都是具有保肝作用的潜在植物。我们的结论是，这些植物化学物质和上述植物提取物将被用于治疗各种肝脏疾病，未来还需要更多的研究来开发更安全、更有效的植物化学药物。
