Dawson P A, Filipe M I, Bussey H J
Histopathology. 1977 Mar;1(2):105-13. doi: 10.1111/j.1365-2559.1977.tb01649.x.
Colectomy specimens from 6 cases of familial polyposis coli (FPC) were examined. Macroscopically normal mucosa between polyps was taken at intervals along the ascending, transverse and descending colons and studied at EM level. All three regions show the same cell populations varying only in their ratio and height of the epithelium. The same cell types seen in the normal crypt epithelium are present in the mucosa from FPC. As in the normal, 'intermediate' cells are present in FPC but they are less conspicuous than in the mucosa adjacent to colonic carcinoma. However, there are ultrastructural features which distinguish the "normal" mucosa in FPC from the true normal: (a) the presence of "clear columnar" cells; (b) increased vesiculation in the absorptive cells; (c) large number of lysosomes; and (d) the presence of small electron-dense bodies. The ultrastructure of the "clear columnar" cells suggests their being incompletely differentiated cells, thus raising the possibility that their presence in the upper crypt and surface epithelium may represent an early stage in the process of polyp and cancer formation.
对6例家族性结肠息肉病（FPC）的结肠切除术标本进行了检查。在息肉之间的大体正常黏膜处，沿着升结肠、横结肠和降结肠每隔一段距离取材，并进行电镜水平的研究。所有三个区域都显示出相同的细胞群体，只是上皮细胞的比例和高度有所不同。FPC黏膜中存在正常隐窝上皮中所见的相同细胞类型。与正常情况一样，FPC中存在“中间”细胞，但它们不如结肠癌旁黏膜中的明显。然而，有一些超微结构特征将FPC中的“正常”黏膜与真正的正常黏膜区分开来：（a）“透明柱状”细胞的存在；（b）吸收细胞中囊泡化增加；（c）大量溶酶体；（d）小电子致密体的存在。“透明柱状”细胞的超微结构表明它们是未完全分化的细胞，因此增加了它们在上部隐窝和表面上皮中的存在可能代表息肉和癌症形成过程早期阶段的可能性。
