Department of Ophthalmology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, People's Republic of China.
Medal Eye Institute, Chongqing, China.
BMC Ophthalmol. 2023 Apr 6;23(1):143. doi: 10.1186/s12886-023-02891-8.
To investigate potential impact factors associated with corneal biomechanical properties in Chinese myopia and further to investigate quantifying corneal biomechanics in clinical work.
Three hundred fifty-five eyes from 181 healthy myopic subjects with a mean age of 25.1 ± 9.4 were recruited in this study. Each patient carried out a comprehensive ophthalmic examination, including corneal hysteresis(CH), corneal resistance factor(CRF), central corneal thickness(CCT), axial length(AL), intraocular pressure(IOP), spherical equivalence(SE) and corneal curvature (K). CH and CRF were measured with the ocular response analyzer(ORA). To analyze the corneal biomechanical characteristics of myopia patients and their association with other parameters.
The multiple linear regression analysis showed that CH was positively associated with CCT, and corneal curvature (all with P < 0.05) and negatively associated with SE and AL)(all with P < 0.05); CRF was positively correlated with CCT, corneal curvature and IOP(all with P < 0.05), but negatively correlated with SE and AL(all with P < 0.05). The CH and CRF values in children group were both higher than adults group (≥ 18 years old) (P < 0.05), but it attributed to that the CCT of children was thicker than adults. Excluding factor of CCT, there was no significant difference in CH and CRF between children group and adult group. Excluding factor of CCT, there was no significant difference in CH and CRF among different stage of age (age 18-48).
The CCT played the most important role of affecting the CH and CRF. The SE, corneal curvature, AL and IOP had a certain influence on corneal biomechanics. Whether the CH and CRF values of individual patient are normal in clinical work, it should refer to the CH and CRF values corresponding CCT sectional range and SE.
探讨中国人近视眼角膜生物力学特性的相关影响因素，并进一步探讨在临床工作中定量评估角膜生物力学的方法。
本研究共纳入 181 例平均年龄 25.1±9.4 岁的近视患者的 355 只眼。所有患者均进行了全面的眼科检查，包括角膜滞后量（CH）、角膜阻力因子（CRF）、中央角膜厚度（CCT）、眼轴长度（AL）、眼压（IOP）、等效球镜（SE）和角膜曲率（K）。CH 和 CRF 通过眼反应分析仪（ORA）进行测量。分析近视患者的角膜生物力学特征及其与其他参数的相关性。
多元线性回归分析显示，CH 与 CCT、角膜曲率（均 P<0.05）呈正相关，与 SE 和 AL（均 P<0.05）呈负相关；CRF 与 CCT、角膜曲率和 IOP（均 P<0.05）呈正相关，与 SE 和 AL（均 P<0.05）呈负相关。儿童组的 CH 和 CRF 值均高于成年组（≥18 岁）（P<0.05），但这归因于儿童的 CCT 较厚。排除 CCT 因素后，儿童组和成年组的 CH 和 CRF 值无显著差异。排除 CCT 因素后，不同年龄组（18-48 岁）之间的 CH 和 CRF 值无显著差异。
CCT 对 CH 和 CRF 的影响最大。SE、角膜曲率、AL 和 IOP 对角膜生物力学有一定影响。在临床工作中，个体患者的 CH 和 CRF 值是否正常，应参考相应 CCT 节段范围和 SE 的 CH 和 CRF 值。
