Lu Li-Li, Hu Xiao-Juan, Yang Yan, Xu Shen, Yang Shi-Yong, Zhang Cui-Yu, Zhao Qing-Ya
Department of Ophthalmology, Cangzhou Aier Eye Hospital, Cangzhou 061000, Hebei Province, China.
World J Clin Cases. 2022 Feb 16;10(5):1548-1556. doi: 10.12998/wjcc.v10.i5.1548.
Recent epidemiological studies have shown that general eye measurement parameters and corneal biomechanical properties can predict the speed of myopic progression in children.
To investigate the correlation between the onset and progression of myopia and corneal biomechanical parameters in children.
The study included 102 cases in the emmetropia group, 207 cases in the myopic group, and 109 cases in the hyperopic group. The correlation between the change in corneal biomechanical indexes and the change in general ocular measurement parameters was analyzed. A one-way ANOVA test compared general ocular measurement and corneal biomechanical parameters. Pearson's correlation coefficient was analyzed to correlate corneal biomechanical and general ocular measurement parameters.
The general ophthalmometric parameters: Spherical equivalent (SE), intraocular pressure (IOP), and axial length (AL), differed significantly among subjects in myopia, emmetropia, and hyperopic groups. Children's SE positively correlated with corneal biomechanical parameters: Second velocity of applanation (A2V), peak distance (PD), and deformation amplitude (DA) ( < 0.05), and second applanation length (A2L) ( < 0.05). But it was negatively correlated with PD, DA and integral radius (IR) ( < 0.05). Also, IOP was negatively correlated with A2L and IR ( < 0.05). AL positively correlated with A2V and negatively correlated with second applanation time (A2T), highest concavity, and PD. Central corneal thickness positively correlated with first applanation length, first applanation time, first applanation deformation amplitude, A2V, A2L, A2T, second applanation deformation amplitude, central curvature radius at highest concavity (HCR), PD, DA, IR, ambrosia relational thickness-horizontal, first applanation stiffness parameter, corvis biomechanical index, topographic and biomechanics index and the first velocity of applanation. The general ocular Km in children positively correlated with corneal biomechanical parameters DA and IR and negatively correlated with A2L, HCR, and PD. There was a positive correlation between the general ocular measurement parameters ΔSE and corneal biomechanical parameters ΔA2V and ΔA2L, and a negative correlation with ΔIR. The increase in general ocular measurement parameter ΔKm positively correlated with changes in corneal biomechanical parameters, ΔDA and ΔIR, and negatively correlated with ΔHCR and ΔPD.
Myopia development in children was associated with multiple corneal biomechanical parameters.
近期流行病学研究表明，一般眼测量参数和角膜生物力学特性可预测儿童近视进展速度。
探讨儿童近视的发生与进展和角膜生物力学参数之间的相关性。
研究纳入正视组102例、近视组207例、远视组109例。分析角膜生物力学指标变化与一般眼测量参数变化之间的相关性。采用单因素方差分析比较一般眼测量参数和角膜生物力学参数。分析Pearson相关系数以关联角膜生物力学参数和一般眼测量参数。
一般眼测量参数：等效球镜度（SE）、眼压（IOP）和眼轴长度（AL），在近视、正视和远视组受试者之间存在显著差异。儿童的SE与角膜生物力学参数：第二次压平速度（A2V）、峰值距离（PD）和变形幅度（DA）呈正相关（<0.05），与第二次压平长度（A2L）呈正相关（<0.05）。但与PD、DA和积分半径（IR）呈负相关（<0.05）。此外，IOP与A2L和IR呈负相关（<0.05）。AL与A2V呈正相关，与第二次压平时间（A2T）、最大凹陷度和PD呈负相关。中央角膜厚度与第一次压平长度、第一次压平时间、第一次压平变形幅度、A2V、A2L、A2T、第二次压平变形幅度、最大凹陷度处的中央曲率半径（HCR）、PD、DA、IR、水平向角膜相关厚度、第一次压平刚度参数、Corvis生物力学指数、地形和生物力学指数以及第一次压平速度呈正相关。儿童的一般眼Km与角膜生物力学参数DA和IR呈正相关，与A2L、HCR和PD呈负相关。一般眼测量参数ΔSE与角膜生物力学参数ΔA2V和ΔA2L呈正相关，与ΔIR呈负相关。一般眼测量参数ΔKm的增加与角膜生物力学参数ΔDA和ΔIR的变化呈正相关，与ΔHCR和ΔPD呈负相关。
儿童近视发展与多个角膜生物力学参数相关。
