Daei Sorkhabi Amin, Sarkesh Aila, Mohammadzadeh Nader, Shiri Aghbash Parisa, Bannazadeh Baghi Hossein
Immunology Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran.
Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Tanaffos. 2022 Mar;21(3):317-329.
The objective of this research is to analyze influenza-induced complications, symptoms, and the interaction of morbidity and mortality rates in hospitalized influenza cases based on age-sex dispersion, influenza virus subtype, prescribed medications, and underlying conditions.
We performed this retrospective study using a dataset of 10,517 hospitalized individuals, including 3,101 laboratory-confirmed influenza cases from patients of all ages who had attended hospitals in the Northwest of Iran due to respiratory complications.
The most prevalent strain which circulated annually was influenza A/H3N2. In contrast to previous studies, our findings suggested that influenza A/H1N1 has the highest mortality rate and the most severe complications.Regardless of virus type/subtype, the most susceptible age group for influenza was 0-9 years old in both males and females. Meanwhile the high-risk age group among males was 50-59 years old and among females were over 80 age group (mortality rate ≈ 20%). Chronic obstructive pulmonary disease (COPD) (32%) and cardiovascular disease (CVD) (30%) were the most prevalent active underlying diseases among the patients who died, with the latter being more prevalent in males over the age of 70. Patients with a history of chemotherapy had the highest mortality rate. Patients who were prescribed a combination of antibiotics and antivirals had better outcomes with lowest mortality rate.
Our findings demonstrated that annual influenza seasons are often marked by changes in influenza types and subtypes, with variations in the severity. Development of a standardized set of arrays that best correspond with infections, can be useful in guiding diagnostic and therapeutic decisions.
本研究的目的是基于年龄性别分布、流感病毒亚型、所开药物和基础疾病，分析住院流感病例中流感引发的并发症、症状以及发病率和死亡率的相互作用。
我们使用了10517名住院患者的数据集进行这项回顾性研究，其中包括3101例经实验室确诊的流感病例，这些病例来自伊朗西北部因呼吸道并发症住院的各年龄段患者。
每年流行的最常见毒株是甲型H3N2流感。与先前的研究不同，我们的研究结果表明，甲型H1N1流感的死亡率最高，并发症最严重。无论病毒类型/亚型如何，流感最易感的年龄组在男性和女性中均为0至9岁。同时，男性中的高危年龄组为50至59岁，女性中的高危年龄组为80岁以上（死亡率约为20%）。慢性阻塞性肺疾病（COPD）（32%）和心血管疾病（CVD）（30%）是死亡患者中最常见的活动性基础疾病，后者在70岁以上男性中更为普遍。有化疗史的患者死亡率最高。同时使用抗生素和抗病毒药物的患者预后较好，死亡率最低。
我们的研究结果表明，每年的流感季节通常以流感类型和亚型的变化为特征，严重程度也有所不同。开发一套与感染最相符的标准化阵列，可能有助于指导诊断和治疗决策。
