化学重编程驶上快车道。

Chemical reprogramming takes the fast lane.

机构信息

Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, TX, USA; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA.

出版信息

Cell Stem Cell. 2023 Apr 6;30(4):335-337. doi: 10.1016/j.stem.2023.03.001.

DOI:10.1016/j.stem.2023.03.001

PMID:37028396

Abstract

Small molecule-induced cell fate transitions are characterized by low efficiency and slow kinetics. An optimized chemical reprogramming approach now facilitates the robust and rapid conversion of somatic cells to pluripotent stem cells, unlocking exciting avenues to study and manipulate human cell identity.

摘要

小分子诱导的细胞命运转变的特点是效率低和动力学慢。一种优化的化学重编程方法现在可以促进体细胞向多能干细胞的高效快速转化，为研究和操纵人类细胞特性开辟了令人兴奋的途径。