Pharmacological and Diagnostic Research Center, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman 19328, Jordan; Institute of Cancer Therapeutics, University of Bradford, Bradford, West Yorkshire BD7 1DP, United Kingdom.
Pharmacological and Diagnostic Research Center, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman 19328, Jordan.
Life Sci. 2023 Jun 15;323:121662. doi: 10.1016/j.lfs.2023.121662. Epub 2023 Apr 5.
The signalling system known as mammalian target of rapamycin (mTOR) is believed to be required for several biological activities involving cell proliferation. The serine-threonine kinase identified as mTOR recognises PI3K-AKT stress signals. It is well established in the scientific literature that the deregulation of the mTOR pathway plays a crucial role in cancer growth and advancement. This review focuses on the normal functions of mTOR as well as its abnormal roles in cancer development.
被称为雷帕霉素靶蛋白（mTOR）的信号系统被认为是涉及细胞增殖的几种生物活性所必需的。已鉴定出的丝氨酸-苏氨酸激酶 mTOR 可识别 PI3K-AKT 应激信号。科学文献中已经明确指出，mTOR 途径的失调在癌症的生长和进展中起着至关重要的作用。本篇综述重点介绍了 mTOR 的正常功能及其在癌症发展中的异常作用。
