Rauf Abdur, Akram Zuneera, Hafeez Nabia, Khalil Anees Ahmed, Khalid Ahood, Hemeg Hassan A, Aljohani Abdullah S M, Al Abdulmonem Waleed, Quradha Mohammed Mansour, Qahtan Abdulkader Moqbel Farhan
Department of Chemistry University of Swabi Anbar Khyber Pakhtunkhwa Pakistan.
Department of Pharmacology, Faculty of Pharmaceutical Sciences Baqai Medical University Karachi Pakistan.
Food Sci Nutr. 2024 Jun 17;12(9):6047-6054. doi: 10.1002/fsn3.4237. eCollection 2024 Sep.
Cancer, characterized as one of the leading causes of death owing to its heterogeneity and complexity, hence poses a significant challenge to health care system across the globe. Current therapies for cancer curtailment are considered to have associated side effects, therefore discovery of novel alternative approaches is need of the time. In this context, natural products have attained an essential spot in the scientific community for the development of novel cancer treatments. Among others, Diospyrin, a bis-hydroxy-naphthoquinonoid, is a vital bioactive component present in various and species. The bioactivity associated with Diospyrin's makes it a promising "lead molecule" for new chemotherapy. In this review, biosynthesis of Diospyrin and its analogues along with their anticancer activities has been discussed. Moreover, this review briefly discusses probable modes of action of Diospyrin and its analogues by targeting the molecular signal transduction pathways. This review also highlights the toxicological and clinical implications of diospyrin and its derivatives. Further pharmacological and pharmacogenetic studies are required to better understand the anticancer potential of Diospyrin and its analogues at the molecular and genetic levels.
癌症因其异质性和复杂性而成为主要死因之一，因此对全球医疗保健系统构成了重大挑战。目前用于遏制癌症的疗法被认为存在相关副作用，因此，当下需要发现新的替代方法。在这种背景下，天然产物在科学界开发新型癌症治疗方法方面占据了重要地位。其中，柿皮素，一种双羟基萘醌，是存在于各种物种中的重要生物活性成分。与柿皮素相关的生物活性使其成为新型化疗的有前景的“先导分子”。在这篇综述中，讨论了柿皮素及其类似物的生物合成及其抗癌活性。此外，本综述简要讨论了柿皮素及其类似物通过靶向分子信号转导途径的可能作用模式。本综述还强调了柿皮素及其衍生物的毒理学和临床意义。需要进一步的药理学和药物遗传学研究，以在分子和基因水平上更好地了解柿皮素及其类似物的抗癌潜力。
