School of Chemistry, Xi'an Key Laboratory of Sustainable Energy Material Chemistry, Xi'an Jiaotong University, Xi'an 710049, PR China.
The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710061, PR China.
Carbohydr Polym. 2023 Jul 1;311:120780. doi: 10.1016/j.carbpol.2023.120780. Epub 2023 Mar 4.
The choice of hemostatic technique is a curial concern for surgery and as first-aid treatment in combat. To treat uncontrolled bleeding in complex wound environments, chitosan-based hemostatic sponges have attracted significant attention in recent years because of the excellent biocompatibility, degradability, hemostasis and antibacterial properties of chitosan and their unique sponge-like morphology for high fluid absorption rate and priority aggregation of blood cells/platelets to achieve rapid hemostasis. In this review, we provide a historical perspective on the use of chitosan hemostatic sponges as the new generation of hemostatic materials for uncontrolled bleeding emergencies in complex wounds. We summarize the modification of chitosan, review the current status of preparation protocols of chitosan sponges based on various composite systems, and highlight the recent achievements on the detailed breakdown of the existing chitosan sponges to present the relationship between their composition, physical properties, and hemostatic capacity. Finally, the future opportunities and challenges of chitosan hemostatic sponges are also proposed.
止血技术的选择是手术和战斗中急救治疗的关键关注点。为了治疗复杂伤口环境中的失控性出血，近年来壳聚糖基止血海绵由于壳聚糖具有优异的生物相容性、可降解性、止血和抗菌性能，以及其独特的海绵状形态，可实现高流体吸收率和优先聚集血细胞/血小板以实现快速止血，因此引起了人们的极大关注。在本综述中，我们提供了壳聚糖止血海绵作为新一代止血材料在复杂伤口失控性出血紧急情况中应用的历史视角。我们总结了壳聚糖的改性，回顾了基于各种复合体系的壳聚糖海绵制备方案的现状，并重点介绍了最近在详细剖析现有壳聚糖海绵方面的进展，以展示其组成、物理性能和止血能力之间的关系。最后，还提出了壳聚糖止血海绵的未来机遇和挑战。
