Department of Burns and Plastic Surgery & Wound Repair Surgery, the Lanzhou University Second Hospital, Lanzhou, Gansu, China.
Mol Biol Rep. 2023 Jun;50(6):5355-5367. doi: 10.1007/s11033-023-08392-7. Epub 2023 Apr 8.
The issue of delayed wound healing or nonhealing in diabetic patients presents a challenge for modern medicine. A number of attempts have been made to understand the mechanisms behind diabetic wound. In a hyperglycemic environment, increased intracellular reactive oxygen species (ROS) disturb the balance between oxidation and antioxidant, causing the wound environment to deteriorate. It has been established that the nuclear factor E2-related factor 2 (Nrf2) and nuclear factor-kappa B (NF-κB) pathways play an important role in regulating inflammation and oxidative stress. Several potential treatment strategies involving Nrf2 and/or NF-κB pathways have been explored in previous studies. Hence, we analyzed mechanisms and changes in Nrf2 and NF-κB pathways in response to oxidative stress and inflammation in diabetic environment. Additionally, we reviewed potential treatment strategies from the past five years for diabetic wound by Nrf2 and/or NF-κB pathways, including receptor agonists, vitamins, hormones, exosomes, drugs, plants, and biomaterials. It may be useful to develop drugs to promote diabetic wound healing.
糖尿病患者的伤口愈合延迟或不愈合问题对现代医学提出了挑战。人们已经尝试了多种方法来了解糖尿病伤口背后的机制。在高血糖环境中，细胞内活性氧（ROS）增加会破坏氧化和抗氧化之间的平衡，导致伤口环境恶化。已经确定核因子 E2 相关因子 2（Nrf2）和核因子-κB（NF-κB）途径在调节炎症和氧化应激方面起着重要作用。在以前的研究中，已经探索了几种涉及 Nrf2 和/或 NF-κB 途径的潜在治疗策略。因此，我们分析了 Nrf2 和 NF-κB 途径在糖尿病环境中对氧化应激和炎症的反应机制和变化。此外，我们回顾了过去五年中通过 Nrf2 和/或 NF-κB 途径治疗糖尿病伤口的潜在治疗策略，包括受体激动剂、维生素、激素、外泌体、药物、植物和生物材料。开发促进糖尿病伤口愈合的药物可能会有所帮助。
