Shang Jinxiang, Jin Cong, Wang Fei, Zhang Zhenyu, Xie Lu, Zhou Qingbo, Wang Yaqing, Xu Xinfang, Zhang Songou, Li Jianlei
Department of Orthopedics, Affiliated Hospital of Shaoxing University, Shaoxing City, Zhejiang Province, China.
Department of Orthopedics, Shaoxing People's Hospital, Shaoxing City, Zhejiang Province, China.
Medicine (Baltimore). 2025 Aug 1;104(31):e42716. doi: 10.1097/MD.0000000000042716.
Diabetic foot, a common complication of diabetes, impairs wound healing, leading to ulcers and an increased risk of amputation. Growth factors play a critical role in the management of diabetic foot, influencing wound repair and tissue regeneration. This study employs bibliometric analysis to assess research on growth factors in diabetic foot and predict future research trends.
Scholarly articles published between January 1, 2008, and March 31, 2024, were retrieved from the Web of Science Core Collection database. Analytical and visualization tools such as VOSviewer, CiteSpace, R software, PRISM, and Scimago were utilized for the study.
Over the past 17 years, the number of publications has steadily increased. Aristidis Veves is the most prominent author, with Harvard University being the leading institution. The most cited papers are "Recent Advances in the Development of Wound Dressings for Diabetic Foot Ulcer Treatment" and "Wound Healing and Its Impairment in the Diabetic Foot." Key research areas include cellular mechanisms, economic burden, and treatment targets. Current research hotspots focus on oxidative stress and diabetic wound healing, with future trends leaning toward personalized medicine and advanced technologies.
This bibliometric analysis highlights current trends in growth factor research for diabetic foot, emphasizing oxidative stress and personalized medicine as emerging areas. These findings provide valuable insights for future research and potential improvements in treatment strategies, with the goal of enhancing patient outcomes and reducing the burden of diabetic foot complications.
糖尿病足是糖尿病常见的并发症，会损害伤口愈合，导致溃疡并增加截肢风险。生长因子在糖尿病足的治疗中起着关键作用，影响伤口修复和组织再生。本研究采用文献计量分析方法评估糖尿病足生长因子的研究情况并预测未来研究趋势。
从Web of Science核心合集数据库中检索2008年1月1日至2024年3月31日发表的学术文章。研究使用了VOSviewer、CiteSpace、R软件、PRISM和Scimago等分析和可视化工具。
在过去17年中，出版物数量稳步增加。阿里斯蒂迪斯·韦韦斯是最杰出的作者，哈佛大学是主要机构。被引用最多的论文是《糖尿病足溃疡治疗伤口敷料开发的最新进展》和《糖尿病足的伤口愈合及其损伤》。关键研究领域包括细胞机制、经济负担和治疗靶点。当前的研究热点集中在氧化应激和糖尿病伤口愈合，未来趋势倾向于个性化医疗和先进技术。
这项文献计量分析突出了糖尿病足生长因子研究的当前趋势，强调氧化应激和个性化医疗是新兴领域。这些发现为未来研究和治疗策略的潜在改进提供了有价值的见解，目标是改善患者预后并减轻糖尿病足并发症的负担。
