Department of Infectious Diseases and Virology, School of Public Health, University of Pittsburgh, 130 De Soto Street, Pittsburgh, PA, 15261, USA.
Department of Public Health Sciences, University of Connecticut School of Medicine, Farmington, CT, USA.
AIDS Behav. 2023 Oct;27(10):3272-3284. doi: 10.1007/s10461-023-04047-7. Epub 2023 Apr 8.
This study examined the hypothesis that HIV-related stigma mediates the effect of alcohol use on health-related quality of life (HRQoL) among alcohol consuming Indian men living with HIV (PLWH). The study used baseline data from a randomized controlled clinical trial entitled 'Alcohol and ART adherence: Assessment, Intervention, and Modeling in India. Participants completed surveys assessing demographic characteristics, alcohol use, HIV-related stigma, HRQoL. Mediation analysis was conducted to establish the mediation effect of HIV-related stigma on the relationship between alcohol use and HRQoL. The final mediation model showed that the effect of alcohol use on HRQoL were partially mediated by overall HIV-related stigma. Specially, 27.1% of the effects of alcohol use on HRQoL was mediated through overall HIV stigma. In the HIV stigma subdomain analyses, negative self-image mediated 14% and concerns with public attitudes (anticipated stigma) mediated 17.3% of the effect of alcohol use on HRQoL respectively. The findings suggest that efforts to reduce the negative impact of alcohol use on HRQoL and improve HRQoL among PLWH should include interventions addressing both alcohol use and specific forms of HIV-related stigma.
在印度 HIV 阳性男性饮酒者（PLWH）中，HIV 相关耻辱感在酒精使用对健康相关生活质量（HRQoL）的影响中起中介作用。该研究使用了一项名为“印度的酒精和 ART 依从性：评估、干预和建模”的随机对照临床试验的基线数据。参与者完成了评估人口统计学特征、酒精使用、HIV 相关耻辱感和 HRQoL 的调查。进行了中介分析，以确定 HIV 相关耻辱感在酒精使用与 HRQoL 之间的关系中的中介效应。最终的中介模型表明，酒精使用对 HRQoL 的影响部分受到 HIV 相关耻辱感的中介作用。具体来说，酒精使用对 HRQoL 的影响有 27.1%是通过整体 HIV 耻辱感来介导的。在 HIV 耻辱感子领域分析中，负性自我形象介导了酒精使用对 HRQoL 影响的 14%，公众态度的担忧（预期耻辱感）介导了 17.3%。研究结果表明，减少酒精使用对 HRQoL 的负面影响和改善 PLWH 的 HRQoL 的努力应该包括针对酒精使用和特定形式的 HIV 相关耻辱感的干预措施。
