Brooks D P, Share L, Crofton J T
Neuroendocrinology. 1986;42(5):416-20. doi: 10.1159/000124480.
The role of central adrenergic receptors in the control of vasopressin release was studied in the conscious rat. Norepinephrine (10 micrograms) and the alpha-1 agonist, phenylephrine (50 micrograms), administered intracerebroventricularly resulted in significant increases in the plasma vasopressin concentration and blood pressure. The alpha-2 agonist, BHT 933 (50 micrograms) and the beta agonist, isoproterenol (10 micrograms) both caused a significant decrease in the plasma vasopressin concentration with only small changes in blood pressure. The central administration of the alpha-1 antagonist corynanthine (20 micrograms) had no effect on the plasma vasopressin concentration; however, increases in plasma vasopressin levels were observed when either the alpha-2 antagonist yohimbine (20 micrograms) or the beta antagonist propranolol (20 micrograms) were given. It is concluded that central noradrenergic pathways may play an important role in the control of vasopressin release and that this control may involve alpha-1, alpha-2 and beta adrenoreceptors.
在清醒大鼠中研究了中枢肾上腺素能受体在血管加压素释放调控中的作用。脑室内注射去甲肾上腺素（10微克）和α-1激动剂去氧肾上腺素（50微克）会导致血浆血管加压素浓度和血压显著升高。α-2激动剂BHT 933（50微克）和β激动剂异丙肾上腺素（10微克）均导致血浆血管加压素浓度显著降低，而血压仅有微小变化。中枢给予α-1拮抗剂育亨宾（20微克）对血浆血管加压素浓度无影响；然而，给予α-2拮抗剂育亨宾（20微克）或β拮抗剂普萘洛尔（20微克）时，可观察到血浆血管加压素水平升高。得出的结论是，中枢去甲肾上腺素能通路可能在血管加压素释放的调控中起重要作用，且这种调控可能涉及α-1、α-2和β肾上腺素能受体。
