Lewis S J, Quinn M J, Fennessy M R, Jarrott B
Neurosci Lett. 1986 Mar 28;65(1):84-8. doi: 10.1016/0304-3940(86)90124-2.
The intracerebroventricular injection of the mast cell degranulator, compound 48/80 (C48/80, 10 micrograms/kg), produced a marked behavioural syndrome in rats which included head and body shakes, paw tremor, excessive grooming, unusual posture and gait, mild diarrhoea, piloerection, extreme agitation and irritability to touch, sedation and catatonia. Fifteen minutes after C48/80, the histamine concentrations were decreased significantly in all brain regions examined, i.e. the cortex, cerebellum, midbrain, medulla oblongata-pons (MO-P) and hypothalamus. The noradrenaline (NA) concentrations were decreased in the cerebellum, hypothalamus and MO-P, whereas the dopamine (DA) content was decreased in the MO-P only. The concentrations of serotonin were not affected. As such, the behaviours following the acute degranulation of brain mast cells by C48/80 may result predominantly from the release of histamine and possibly NA and DA.
向大鼠脑室内注射肥大细胞脱颗粒剂化合物48/80（C48/80，10微克/千克），可使大鼠出现明显的行为综合征，包括头部和身体颤抖、爪部震颤、过度梳理毛发、异常姿势和步态、轻度腹泻、竖毛、极度激动以及对触摸敏感、镇静和紧张症。注射C48/80后15分钟，在所检测的所有脑区，即皮层、小脑、中脑、延髓-脑桥（MO-P）和下丘脑，组胺浓度均显著降低。小脑、下丘脑和MO-P中的去甲肾上腺素（NA）浓度降低，而仅MO-P中的多巴胺（DA）含量降低。血清素浓度未受影响。因此，C48/80使脑肥大细胞急性脱颗粒后的行为可能主要是由组胺以及可能的NA和DA释放所致。
