Rodrigues Arthur Nascimento, Dias Apio Ricardo Nazareth, Paranhos Alna Carolina Mendes, Silva Camilla Costa, Bastos Thalita da Rocha, de Brito Bárbara Barros, da Silva Nívia Monteiro, de Sousa Emanuel de Jesus Soares, Quaresma Juarez Antônio Simões, Falcão Luiz Fábio Magno
Center for Biological Health Sciences, State University of Pará, Belém, Pará, Brazil.
Tropical Medicine Center, Federal University of Pará, Belém, Pará, Brazil.
Front Neurol. 2023 Mar 23;14:1149294. doi: 10.3389/fneur.2023.1149294. eCollection 2023.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can exacerbate previous headache disorders or change the type of pain experienced from headaches. This study aimed to investigate the clinical features of Long COVID headaches.
This was a cross-sectional, descriptive, and analytical observational study that included 102 patients (with previous headache, = 50; without previous headache, = 52) with long COVID and headache complaints. The Migraine Disability Assessment Test and Visual Analog Pain Scale were used to collect participants' headache data according to a standardized protocol.
The patients in this study who reported experiencing headaches before COVID-19 had longer headache duration in the long COVID phase than that in the pre-long COVID phase ( = 0.031), exhibited partial improvement in headache symptoms with analgesics ( = 0.045), and had a duration of long COVID of <1 year ( = 0.030). Patients with moderate or severe disability and those classified as having severe headaches in the long COVID phase were highly likely to develop chronic headaches. Hospital admission [odds ratio (OR) = 3.0082; 95% confidence interval (95% CI): 1.10-8.26], back pain (OR = 4.0017; 95% CI: 1.13-14.17), insomnia (OR = 3.1339; 95% CI: 1.39-7.06), and paraesthesia (OR = 2.7600; 95% CI: 1.20-6.33) were associated with headache in these patients.
Headache is a disabling condition in patients with long COVID-19, exacerbating the conditions of those with headaches prior to contracting COVID-19.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染可使既往头痛疾病加重，或改变头痛的疼痛类型。本研究旨在调查新冠后综合征头痛的临床特征。
这是一项横断面、描述性和分析性观察性研究，纳入了102例有新冠后综合征且伴有头痛主诉的患者（既往有头痛史者50例；无既往头痛史者52例）。采用偏头痛残疾评估测试和视觉模拟疼痛量表，根据标准化方案收集参与者的头痛数据。
本研究中报告在新型冠状病毒肺炎（COVID-19）之前有头痛经历的患者，在新冠后综合征阶段的头痛持续时间比新冠后综合征前阶段更长（P = 0.031），使用镇痛药后头痛症状有部分改善（P = 0.045），且新冠后综合征病程<1年（P = 0.030）。在新冠后综合征阶段有中度或重度残疾以及被归类为重度头痛的患者很可能发展为慢性头痛。住院治疗[比值比（OR）= 3.0082；95%置信区间（95%CI）：1.10 - 8.26]、背痛（OR = 4.0017；95%CI：1.13 - 14.17）、失眠（OR = 3.1339；95%CI：1.39 - 7.06）和感觉异常（OR = 2.7600；95%CI：1.20 - 6.33）与这些患者的头痛有关。
头痛是新冠后综合征患者的致残状况，会使感染新冠之前有头痛的患者病情加重。
