Wang Jianxiong, Xiao Xiaowu, Zhou Nian, Zhao Minmin, Lang Shuqin, Ren Qi, Wang Dong, Fu Huizheng
Jiangxi Institute for Drug Control, NMPA Key Laboratory of Quality Evaluation of Traditional Chinese Patent Medicine, Jiangxi Provincial Engineering Research Center of Drug and Medical Device Quality, Nanchang, Jiangxi, 330029, China; Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, 330004, China.
Jiangxi Institute for Drug Control, NMPA Key Laboratory of Quality Evaluation of Traditional Chinese Patent Medicine, Jiangxi Provincial Engineering Research Center of Drug and Medical Device Quality, Nanchang, Jiangxi, 330029, China.
Phytochemistry. 2023 Jun;210:113670. doi: 10.1016/j.phytochem.2023.113670. Epub 2023 Apr 8.
Ten previously undescribed labdane-type triterpenoids, rubochingosides A - J (1-10), were isolated from the leaves of Rubus chingii Hu. Their structures were elucidated by spectroscopic and chemical methods. The cytotoxicity of all isolated compounds was tested against five human tumor cell lines (Bel-7402, Caski, BGC-823, A2780, and HCT-116). Among them, compounds 4 and 8 showed cytotoxic activities against Bel-7402 and A2780 cells with IC values of 10.43 ± 0.51 and 29.03 ± 2.94 μM, respectively; Compound 8 exhibited cytotoxic activities against Bel-7402 and HCT-116 cells with IC values of 17.78 ± 1.54 and 26.23 ± 6.14 μM, respectively.
从掌叶覆盆子叶中分离出10个新的贝壳杉烷型三萜，rubochingosides A - J（1 - 10）。通过光谱和化学方法阐明了它们的结构。测试了所有分离化合物对五种人类肿瘤细胞系（Bel - 7402、Caski、BGC - 823、A2780和HCT - 116）的细胞毒性。其中，化合物4和8对Bel - 7402和A2780细胞显示出细胞毒性活性，IC值分别为10.43±0.51和29.03±2.94μM；化合物8对Bel - 7402和HCT - 116细胞表现出细胞毒性活性，IC值分别为17.78±1.54和26.23±6.14μM。
