Department of Food Science, Purdue University, West Lafayette, IN, 47906, USA.
Diversey Inc., Charlotte, NC, 28273, USA.
Sci Rep. 2023 Apr 10;13(1):5849. doi: 10.1038/s41598-023-32876-y.
There has been an increase in Candida auris healthcare-associated infections, which result from cross-contamination from surfaces and equipment. In this study, we tested the efficacies of EPA-registered disinfectant towelettes products that are increasingly used for infection control against C. auris at a range of contact times following modifications to standard EPA protocol MB-33-00. Hydrogen peroxide (HP)-based disinfectant towelettes were more efficacious against C. auris than the quaternary ammonium chloride (QAC)-alcohol-based disinfectant towelettes irrespective of tested contact times. Thirty s contact time was significantly less effective in reducing C. auris compared to 1-, 2-, 3-, and 10-min contact times. However, there were no statistically significant differences in the level of disinfection among 1-min and longer contact times regardless of product chemistry. None of the products achieved a standard six-log reduction at any tested contact times. Overall, the HP-based disinfectant towelette was significantly more fungicidal than the QAC-alcohol-based disinfectant towelette. For all product types, 30 s contact time did not achieve the same level of disinfection as 1-min or longer contact times. Overall, disinfectant towelette efficacy is dependent upon product formulation and contact time.
已经有越来越多的耳念珠菌（Candida auris）与医疗保健相关的感染，这些感染源自表面和设备的交叉污染。在这项研究中，我们测试了 EPA 注册的消毒湿巾产品的功效，这些产品在修改了 EPA 标准协议 MB-33-00 后，在不同的接触时间下，越来越多地用于控制感染。过氧化氢（HP）基消毒剂湿巾对耳念珠菌的杀灭效果优于季铵盐-酒精基消毒剂湿巾，无论测试的接触时间如何。与 1、2、3 和 10 分钟的接触时间相比，30 秒的接触时间在减少耳念珠菌方面的效果明显较差。然而，无论产品化学性质如何，在 1 分钟及更长时间的接触时间内，消毒水平没有统计学上的显著差异。在任何测试的接触时间内，没有一种产品达到标准的六对数减少。总体而言，HP 基消毒剂湿巾比季铵盐-酒精基消毒剂湿巾具有更强的杀菌作用。对于所有产品类型，30 秒的接触时间都无法达到 1 分钟或更长时间接触时间的消毒水平。总的来说，消毒剂湿巾的功效取决于产品配方和接触时间。
