Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, UK.
Diversey Inc., Charlotte, NC, USA.
J Hosp Infect. 2019 Sep;103(1):e25-e32. doi: 10.1016/j.jhin.2018.09.016. Epub 2018 Sep 28.
The use of effective cleaning/disinfectant products is important to control pathogens on healthcare surfaces. With the increasing number of wipe products available, there is a concern that combination of a formulation with the wrong material will decrease the efficacy of the product. This study aimed to use a range of efficacy test protocols to determine the efficacy of four formulations before and after binding to three commonly used wiping materials.
Two quaternary ammonium (QAC)-based products, one hydrogen-peroxide-based product and one neutral cleaner were combined with microfibre, cotton or non-woven materials and tested for efficacy against Pseudomonas aeruginosa and Staphylococcus aureus with two surface tests (ASTM E2197-17 and EN13697-15) and two 'product' tests (ASTM E2967-15 and EN16615-15).
Overall, the impact of using different materials on formulation efficacy was limited, except for an alkyl(C)dimethylbenzylammonium chloride-based product used at 0.5% v/v. The hydrogen peroxide product was the most efficacious regardless of the material used. The results from wipe test ASTM E2967-15 were consistent with those from the surface tests, but not with EN16615-15 which was far less stringent.
The use of different wiping cloth materials may not impact severely on the efficacy of potent disinfectants, despite the absorption of different volumes of formulation by the materials. QAC-based formulations may be at higher risk when a low concentration is used. There were large differences in efficacy depending on the standard test performed, highlighting the need for more stringency in choosing the test to make a product claim on label.
有效清洁/消毒剂的使用对于控制医疗表面的病原体至关重要。随着擦拭产品数量的增加，人们担心配方与错误的材料结合会降低产品的功效。本研究旨在使用一系列功效测试方案，在与三种常用擦拭材料结合之前和之后，确定四种配方的功效。
将两种季铵盐（QAC）基产品、一种过氧化氢基产品和一种中性清洁剂与微纤维、棉花或无纺布材料结合，并使用两种表面测试（ASTM E2197-17 和 EN13697-15）和两种“产品”测试（ASTM E2967-15 和 EN16615-15）测试其对铜绿假单胞菌和金黄色葡萄球菌的功效。
总体而言，除了以 0.5%v/v 使用的基于烷基（C）二甲基苄基氯化铵的产品外，不同材料对配方功效的影响有限。过氧化氢产品无论使用何种材料，效果均最佳。ASTM E2967-15 擦拭测试的结果与表面测试一致，但与要求不那么严格的 EN16615-15 不一致。
尽管不同的擦拭布材料会吸收不同体积的配方，但使用不同的擦拭布材料可能不会严重影响强力消毒剂的功效。当使用低浓度时，基于 QAC 的配方可能风险更高。由于所执行的标准测试不同，功效差异很大，这突出表明在选择进行产品标签宣称的测试时需要更严格。
