Thompson D A, Campbell R G
Science. 1977 Dec 9;198(4321):1065-8. doi: 10.1126/science.929188.
Intracellular glucopenia induced by 2-deoxy-D-glucose (2DG) administration in man produces increased hunger ratings and magnitude estimates of pleasantness for sucrose solutions. Augmented food intake substantiates these changes in affective behavior and relieves experimentally induced hunger. Intracellular glucopenia activates counterregulatory mechanisms to raise plasma glucose concentrations. Inducing hunger experimentally with 2DG provides a useful method for studying appetitive behavior in humans. The neurohumoral control of pituitary hormone release and other hypothalamic functions may be examined after 2DG infusion.
在人体中，通过给予2-脱氧-D-葡萄糖（2DG）诱导细胞内葡萄糖缺乏，会使饥饿评分增加，并提高对蔗糖溶液愉悦感的强度估计。食物摄入量增加证实了这些情感行为的变化，并缓解了实验诱导的饥饿感。细胞内葡萄糖缺乏会激活反调节机制以提高血浆葡萄糖浓度。用2DG实验性诱导饥饿为研究人类的食欲行为提供了一种有用的方法。在输注2DG后，可以检查垂体激素释放和其他下丘脑功能的神经体液控制。
