循环长链非编码 RNA 特征与老年人新发糖尿病相关：来自 VITA 队列研究的前瞻性分析。
Circulating Long Noncoding RNA Signatures Associate With Incident Diabetes in Older Adults: A Prospective Analysis From the VITA Cohort Study.
机构信息
Center for Molecular Cardiology, University of Zurich, Zurich, Switzerland.
Center for Translational and Experimental Cardiology (CTEC), Department of Cardiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
出版信息
Diabetes Care. 2023 Jun 1;46(6):1239-1244. doi: 10.2337/dc23-0012.
OBJECTIVE
Long noncoding RNAs (lncRNAs) are involved in diabetogenesis in experimental models, yet their role in humans is unclear. We investigated whether circulating lncRNAs associate with incident type 2 diabetes in older adults.
RESEARCH DESIGN AND METHODS
A preselected panel of lncRNAs was measured in serum of individuals without diabetes (n = 296) from the Vienna Transdanube Aging study, a prospective community-based cohort study. Participants were followed up over 7.5 years. A second cohort of individuals with and without type 2 diabetes (n = 90) was used to validate our findings.
RESULTS
Four lncRNAs (ANRIL, MIAT, RNCR3, and PLUTO) were associated with incident type 2 diabetes and linked to hemoglobin A1c trajectories throughout the 7.5-year follow-up. Similar results (for MIAT and PLUTO also in combined analysis) were obtained in the validation cohort.
CONCLUSIONS
We found a set of circulating lncRNAs that independently portends incident type 2 diabetes in older adults years before disease onset.
目的
长链非编码 RNA（lncRNAs）参与实验模型中的糖尿病发生，但它们在人类中的作用尚不清楚。我们研究了循环 lncRNAs 是否与老年人的 2 型糖尿病发病有关。
研究设计和方法
在维也纳多瑙河衰老研究（一项前瞻性的社区为基础的队列研究）中，对无糖尿病个体（n=296）的血清进行了预先选择的 lncRNAs 检测。参与者在 7.5 年内进行了随访。使用第二个包含有和没有 2 型糖尿病的个体的队列（n=90）来验证我们的发现。
结果
有 4 种 lncRNAs（ANRIL、MIAT、RNCR3 和 PLUTO）与 2 型糖尿病发病相关，并与整个 7.5 年随访期间的血红蛋白 A1c 轨迹有关。在验证队列中也得到了相似的结果（MIAT 和 PLUTO 也在联合分析中）。
结论
我们发现了一组循环 lncRNAs，它们在疾病发病前数年独立预示老年人的 2 型糖尿病发病。
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