Huang Danqing, Cheng Yi, Chen Guopu, Zhao Yuanjin
Institute of Translational Medicine, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210002, China.
State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
Research (Wash D C). 2023;6:0022. doi: 10.34133/research.0022. Epub 2023 Jan 10.
Management of infected wounds has raised worldwide concerns. Attempts in this field focus on the development of intelligent patches for improving the wound healing. Here, inspired by the cocktail treatment and combinational therapy stratagem, we present a novel Janus piezoelectric hydrogel patch via 3-dimensional printing for sonodynamic bacteria elimination and wound healing. The top layer of the printed patch was poly(ethylene glycol) diacrylate hydrogel with gold-nanoparticle-decorated tetragonal barium titanate encapsulation, which realizes the ultrasound-triggered release of reactive oxygen species without leaking nanomaterials. The bottom layer is fabricated with methacrylate gelatin and carries growth factors for the cell proliferation and tissue reconstruction. Based on these features, we have demonstrated in vivo that the Janus piezoelectric hydrogel patch can exert substantial infection elimination activity under the excitation of ultrasound, and its sustained release of growth factors can promote tissue regeneration during wound management. These results indicated that the proposed Janus piezoelectric hydrogel patch had practical significance in sonodynamic infection alleviation and programmable wound healing for treating different clinical diseases.
感染伤口的管理已引起全球关注。该领域的研究致力于开发智能贴片以促进伤口愈合。在此，受鸡尾酒疗法和联合治疗策略的启发，我们通过三维打印提出了一种新型的Janus压电水凝胶贴片，用于声动力除菌和伤口愈合。打印贴片的顶层是聚乙二醇二丙烯酸酯水凝胶，包裹着金纳米颗粒修饰的四方钛酸钡，可实现超声触发的活性氧释放，且不会泄漏纳米材料。底层由甲基丙烯酸明胶制成，携带促进细胞增殖和组织重建的生长因子。基于这些特性，我们在体内证明了Janus压电水凝胶贴片在超声激发下可发挥显著的除菌活性，其生长因子的持续释放可在伤口处理过程中促进组织再生。这些结果表明，所提出的Janus压电水凝胶贴片在减轻声动力感染和可编程伤口愈合以治疗不同临床疾病方面具有实际意义。
