Department of Radiology, University College London Hospitals NHS Foundation Trust, 235 Euston Road, London NW1 2BU, United Kingdom.
Department of Gastroenterology, Northern Hospital, Epping, Melbourne, Australia.
Inflamm Bowel Dis. 2024 Feb 1;30(2):230-239. doi: 10.1093/ibd/izad061.
Inflammatory bowel disease (IBD) is a multisystem disease impacting various body systems including musculoskeletal, ocular, skin, hepatobiliary, pulmonary, cardiac, and haematological systems. The extraintestinal manifestations of IBD are frequent, common in both ulcerative colitis (UC) and Crohn's disease (CD), and impact the morbidity and mortality of patients.
The Embase, Embase classic, and PubMed databases were searched between January 1979 and December 2021. A random effects model was performed to find the pooled prevalence of joint, ocular, and skin extraintestinal manifestations of UC and CD.
Fifty-two studies were included that reported on 352 454 patients. The prevalence of at least 1 joint, ocular, or skin extraintestinal manifestation in all IBD, UC, and CD was 24%, 27%, and 35% respectively. The prevalence between UC and CD were similar for pyoderma gangrenosum and axial joint manifestations. Ocular manifestations were found to be more common in CD than in UC. Peripheral joint manifestations and erythema nodosum were found to be more common in CD than UC.
To our knowledge, this is the first meta-analysis that reports on the prevalence of at least 1 joint, ocular, or skin extraintestinal manifestation in IBD. Our results are largely consistent with figures and statements quoted in the literature. However, our findings are based on significantly larger cohort sizes. Thus, our results have the potential to better power studies and more accurately counsel patients.
炎症性肠病（IBD）是一种多系统疾病，影响包括肌肉骨骼、眼部、皮肤、肝胆、肺、心脏和血液系统在内的多个身体系统。IBD 的肠外表现很常见，在溃疡性结肠炎（UC）和克罗恩病（CD）中都很常见，并且会影响患者的发病率和死亡率。
在 1979 年 1 月至 2021 年 12 月期间，检索了 Embase、Embase classic 和 PubMed 数据库。采用随机效应模型，计算 UC 和 CD 的关节、眼部和皮肤肠外表现的汇总患病率。
共纳入 52 项研究，涉及 352454 例患者。所有 IBD、UC 和 CD 患者至少有一种关节、眼部或皮肤肠外表现的患病率分别为 24%、27%和 35%。UC 和 CD 之间的坏疽性脓皮病和轴性关节表现的患病率相似。眼部表现比 UC 更常见于 CD。CD 比 UC 更常见外周关节表现和结节性红斑。
据我们所知，这是第一项报告 IBD 中至少有一种关节、眼部或皮肤肠外表现的患病率的荟萃分析。我们的结果与文献中的数据和描述基本一致。然而，我们的发现是基于显著更大的队列规模。因此，我们的结果有可能更好地为研究提供动力，并更准确地为患者提供咨询。
