Reinhart Michaela B, Huntington Ciara R, Blair Laurel J, Heniford B Todd, Augenstein Vedra A
Carolinas Medical Center, Charlotte, NC, USA.
Carolinas Medical Center, Charlotte, NC, USA
Surg Innov. 2016 Apr;23(2):166-75. doi: 10.1177/1553350615604053. Epub 2015 Sep 10.
Indocyanine green (ICG) is a dye used in medicine since the mid-1950s for a variety of applications in in cardiology, ophthalmology, and neurosurgery; however, its fluorescent properties have only recently been used in the intraoperative evaluation of tissue perfusion.
A literature review was conducted on the characterization and employment of ICG within the medical field. Historical and current context of ICG was examined while also considering implications for its future use.
ICG is a relatively nontoxic, unstable compound bound by albumin in the intravascular space until rapid clearance by the liver. It has widespread uses in hepatic, cardiac, and ophthalmologic studies, and its use in analyzing tissue perfusion and identifying sentinel lymph nodes in cancer staging is gaining popularity.
ICG has myriad applications and poses low risk to the patient. Its historical uses have contributed to medical knowledge, and it is now undergoing investigation for quantifying tissue perfusion, providing targeted therapies, and intraoperative identification of neurovascular anatomy, ophthalmic structures, and sentinel lymph nodes. New applications of ICG may lead to reduction in postoperative wound-related complications, more effective ophthalmologic procedures, and better detection and treatment of cancer cells.
吲哚菁绿（ICG）自20世纪50年代中期以来一直用于医学领域，在心脏病学、眼科和神经外科有多种应用；然而，其荧光特性直到最近才被用于组织灌注的术中评估。
对ICG在医学领域的特性和应用进行了文献综述。研究了ICG的历史和当前背景，同时也考虑了其未来使用的影响。
ICG是一种相对无毒、不稳定的化合物，在血管内与白蛋白结合，直至被肝脏快速清除。它在肝脏、心脏和眼科研究中有广泛应用，其在分析组织灌注和癌症分期中识别前哨淋巴结方面的应用越来越受欢迎。
ICG有多种应用，对患者风险较低。其历史用途促进了医学知识的积累，目前正在研究其在量化组织灌注、提供靶向治疗以及术中识别神经血管解剖结构、眼科结构和前哨淋巴结方面的应用。ICG的新应用可能会减少术后伤口相关并发症，使眼科手术更有效，并更好地检测和治疗癌细胞。
