Department of Medicine, Cardiology, Angiology, Hemostasis and Intensive Care Medicine, University Medical Center Mannheim, Faculty of Medicine Mannheim, University of Heidelberg, 68135 Mannheim, Germany.
Int J Mol Sci. 2023 Mar 27;24(7):6280. doi: 10.3390/ijms24076280.
Platelets are important cellular targets in cardiovascular disease. Based on insights from basic science, translational approaches and clinical studies, a distinguished anti-platelet drug treatment regimen for cardiovascular patients could be established. Furthermore, platelets are increasingly considered as cells mediating effects "beyond thrombosis", including vascular inflammation, tissue remodeling and healing of vascular and tissue lesions. This review has its focus on the functions and interactions of platelets with potential translational and clinical relevance. The role of platelets for the development of atherosclerosis and therapeutic modalities for primary and secondary prevention of atherosclerotic disease are addressed. Furthermore, novel therapeutic options for inhibiting platelet function and the use of platelets in regenerative medicine are considered.
血小板是心血管疾病的重要细胞靶点。基于基础科学、转化方法和临床研究的见解，可以为心血管病患者建立一种杰出的抗血小板药物治疗方案。此外，血小板越来越被认为是介导“血栓形成以外”作用的细胞，包括血管炎症、组织重塑以及血管和组织损伤的愈合。本综述重点介绍了血小板的功能及其与潜在转化和临床相关性的相互作用。探讨了血小板在动脉粥样硬化发展中的作用以及动脉粥样硬化疾病一级和二级预防的治疗方法。此外，还考虑了抑制血小板功能的新治疗选择以及血小板在再生医学中的应用。
