Sahn S A, Good J T, Potts D E
Chest. 1979 Aug;76(2):198-200. doi: 10.1378/chest.76.2.198.
The rate of success in producing pleural symphysis with intrapleural instillation of sclerosing agents has been variable. Differences in the designs of studies probably account for some of the variability, but the reasons for the remainder are not clear. Since a low pH of the pleural fluid is associated with pleural adhesions and loculations, the pH of the commonly used solutions of sclerosing agents was determined, both in their usual concentrations and when diluted with large quantities of exudative pleural fluid. The buffered solution of tetracycline hydrochloride had the most acidic pH (2.0) and showed little change when diluted by pleural fluid. A 0.5 percent solution of sodium hydroxide had the highest pH (13.0). The remainder of the sclerosing solutions showed a range of pH from 4.3 to 8.7. Experimental and clinical experience suggests that tetracycline consistently has the highest rate of success in producing pleural symphysis. It appears that when proper technique is employed, the pH of the solution of the sclerosing agent is an important determinant of the production of pleural symphysis.
通过胸腔内注入硬化剂来实现胸膜粘连的成功率各不相同。研究设计的差异可能是造成这种差异的部分原因，但其余差异的原因尚不清楚。由于胸腔积液的低pH值与胸膜粘连和分隔有关，因此测定了常用硬化剂溶液在其常规浓度以及用大量渗出性胸腔积液稀释后的pH值。盐酸四环素缓冲溶液的pH值最酸（2.0），用胸腔积液稀释时变化不大。0.5%的氢氧化钠溶液pH值最高（13.0）。其余硬化剂溶液的pH值范围为4.3至8.7。实验和临床经验表明，四环素在产生胸膜粘连方面的成功率始终最高。看来，当采用适当技术时，硬化剂溶液的pH值是产生胸膜粘连的一个重要决定因素。
