Xie Yingying, Qu Peiliu, Guo Liling, Xu Jin, Zhu Liyuan, Tan Yangrong, Wen Tie, Liu Ling
Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha 410011, China.
Research Institute of Blood Lipid and Atherosclerosis, Central South University, Changsha 410011, China.
J Clin Med. 2023 Mar 28;12(7):2539. doi: 10.3390/jcm12072539.
Hypertension (HBP) often occurs together with hypertriglyceridemia which indicates elevated triglyceride (TG) and remnant cholesterol (RC) levels. Non-fasting (i.e., postprandial) blood lipid test after a daily meal has been recommended by the European Atherosclerosis Society (EAS). However, little is known about the difference between fasting and non-fasting cut-off values in assessing high TG (HTG) and high RC (HRC) in HBP outpatients. 225 Chinese outpatients with HBP, including 119 fasting patients (i.e., fasting group) and 106 non-fasting patients (i.e., non-fasting group) were enrolled in this study. Non-fasting levels of blood lipids at 2 h after a daily breakfast were also tested in 33 patients among the fasting group. Venous blood samples were collected. The non-fasting group had significantly higher levels of TG and RC while lower levels of total cholesterol, low-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol than the fasting group ( < 0.05). According to the TG and RC cut-off values of the EAS, the percentages of HTG and HRC in the non-fasting group were 72.6% and 70.8%, respectively, whereas those in the fasting group were 57.1% and 52.9%, respectively. According to the cut-off value of marked HTG commonly used in the Chinese population in clinical practice, the percentage of marked HTG in the non-fasting group was 57.5%, whereas that in the fasting group was 34.5%. However, the percentages of HTG (57.6% vs. 51.5%) and HRC (51.5% vs. 51.5%) marked HTG (30.3% vs. 33.3%) in the fasting state and at 2 h after a daily breakfast in 33 outpatients did not reach statistical significance. Non-fasting blood lipid tests could find more individuals with HTG as well as those with marked HTG among Chinese outpatients with HBP. It indicates that non-fasting blood lipid tests are worth being recommended in patients with HBP.
高血压（HBP）常与高甘油三酯血症同时出现，后者表明甘油三酯（TG）和残留胆固醇（RC）水平升高。欧洲动脉粥样硬化学会（EAS）建议在每日餐后进行非空腹（即餐后）血脂检测。然而，对于高血压门诊患者中，空腹和非空腹临界值在评估高甘油三酯（HTG）和高残留胆固醇（HRC）方面的差异知之甚少。本研究纳入了225名中国高血压门诊患者，包括119名空腹患者（即空腹组）和106名非空腹患者（即非空腹组）。空腹组中的33名患者还检测了每日早餐后2小时的非空腹血脂水平。采集静脉血样本。非空腹组的TG和RC水平显著高于空腹组，而总胆固醇、低密度脂蛋白胆固醇和非高密度脂蛋白胆固醇水平低于空腹组（<0.05）。根据EAS的TG和RC临界值，非空腹组中HTG和HRC的百分比分别为72.6%和70.8%，而空腹组中分别为57.1%和52.9%。根据中国人群临床实践中常用的显著高甘油三酯临界值，非空腹组中显著高甘油三酯的百分比为57.5%，而空腹组中为34.5%。然而，33名门诊患者在空腹状态和每日早餐后2小时时，HTG（57.6%对51.5%）、HRC（51.5%对51.5%）以及显著高甘油三酯（30.3%对33.3%）的百分比差异无统计学意义。非空腹血脂检测可以在中国高血压门诊患者中发现更多的HTG个体以及显著高甘油三酯个体。这表明非空腹血脂检测值得推荐给高血压患者。
