Roses D F, Valensi Q, LaTrenta G, Harris M N
Surg Gynecol Obstet. 1986 May;162(5):449-52.
The clinical course and histopathologic factors of 50 consecutive patients treated for dermatofibrosarcoma protuberans were reviewed. Forty-eight patients were observed until the present time or death. No patient had distant metastases develop, although 16 patients had 18 recurrences of the dermatofibrosarcoma protuberans at the site of initial therapy. There was no correlation between the diameter of the primary lesion and the incidence of recurrence. There was no correlation between the histologic pattern of invasion and recurrence. However, a trend toward decreasing recurrence was noted with increasing minimal margins of resections (41 per cent less than 2 centimeters versus 24 per cent greater than or equal to 2 centimeters). The lowest incidence of recurrence (20 per cent) was noted with minimal margins of resection greater than or equal to 3 centimeters. Five year recurrence free survival rates increased with increasing margins of resection--59 per cent less than 1 centimeter; 66 per cent greater than or equal to 1 centimeter; 70 per cent greater than or equal to 2 centimeters, and 80 per cent greater than or equal to 3 centimeters. No patient had distant metastases and no change in histologic pattern was noted with progressive local recurrence.
回顾了50例连续接受隆突性皮肤纤维肉瘤治疗患者的临床病程和组织病理学因素。48例患者随访至目前或死亡。尽管16例患者在初始治疗部位出现了18次隆突性皮肤纤维肉瘤复发，但无患者发生远处转移。原发灶直径与复发率之间无相关性。侵袭的组织学模式与复发之间无相关性。然而，随着切除切缘最小宽度的增加，复发有减少的趋势（切缘小于2厘米者复发率为41%，切缘大于或等于2厘米者为24%）。切除切缘大于或等于3厘米时复发率最低（20%）。随着切除切缘宽度增加，5年无复发生存率上升——切缘小于1厘米者为59%；切缘大于或等于1厘米者为66%；切缘大于或等于2厘米者为70%；切缘大于或等于3厘米者为80%。无患者发生远处转移，且随着局部复发进展，组织学模式无变化。
