Department of Population Health, New York University Grossman School of Medicine, New York City, NY, USA.
Department of Population Health, New York University Grossman School of Medicine, New York City, NY, USA; Department of Pediatrics, New York University Grossman School of Medicine, New York City, NY, USA; Department of Environmental Medicine, New York University Grossman School of Medicine, New York City, NY, USA.
Sleep Health. 2023 Aug;9(4):467-474. doi: 10.1016/j.sleh.2023.02.001. Epub 2023 Apr 11.
To study associations between nighttime sleep characteristics and time to pregnancy.
Pregnant people age ≥18 years and<18 weeks' gestation were recruited from 3 New York University Grossman School of Medicine affiliated hospitals in Manhattan and Brooklyn (n = 1428) and enrolled into the New York University Children's Health and Environment Study. Participants in the first trimester of pregnancy were asked to recall their time to pregnancy and their sleep characteristics in the 3 months before conception.
Participants who reported sleeping<7 hours per night tended to have shorter time to pregnancy than those who slept 7-9 hours per night (adjusted fecundability odds ratio = 1.16, 95% confidence interval: 0.94, 1.41). Participants with a sleep midpoint of 4 AM or later tended to have longer time to pregnancy compared with those with earlier sleep midpoints (before 4 AM) (adjusted fecundability odds ratio = 0.88, 95% confidence interval: 0.74, 1.04). When stratified by sleep midpoint, sleeping<7 hours was significantly associated with shorter time to pregnancy only among those whose sleep midpoint was before 4 AM (adjusted fecundability odds ratio = 1.33, 95% confidence interval: 1.07, 1.67).
The association of sleep duration with time to pregnancy was modified by chronotype, suggesting that both biological and behavioral aspects of sleep may influence fecundability.
研究夜间睡眠特征与妊娠时间的关系。
在曼哈顿和布鲁克林的 3 所纽约大学格罗斯曼医学院附属医院招募了年龄≥18 岁且妊娠<18 周的孕妇（n=1428），并将其纳入纽约大学儿童健康与环境研究。妊娠早期的参与者被要求回忆她们的妊娠时间和受孕前 3 个月的睡眠特征。
与每晚睡眠 7-9 小时的参与者相比，每晚睡眠<7 小时的参与者妊娠时间更短（调整后的受孕力优势比=1.16，95%置信区间：0.94，1.41）。睡眠中点在凌晨 4 点或更晚的参与者与睡眠中点更早（凌晨 4 点前）的参与者相比，妊娠时间更长（调整后的受孕力优势比=0.88，95%置信区间：0.74，1.04）。按睡眠中点分层后，只有那些睡眠中点在凌晨 4 点之前的参与者，睡眠<7 小时与妊娠时间更短显著相关（调整后的受孕力优势比=1.33，95%置信区间：1.07，1.67）。
睡眠时间与妊娠时间的关系受生物钟的影响，这表明睡眠的生理和行为方面都可能影响生育能力。
