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瑞典移民群体中出现小儿麻痹后综合征的风险。

The risk of post-polio syndrome among immigrant groups in Sweden.

机构信息

Division of Family Medicine and Primary Care, NVS Department, Karolinska Institutet, Alfred Nobels Allé 23, 141 83, Huddinge, Sweden.

Center for Primary Health Care Research, Lund University, Malmö, Sweden.

出版信息

Sci Rep. 2023 Apr 13;13(1):6044. doi: 10.1038/s41598-023-33240-w.

Abstract

To examine the risk of post-polio syndrome (PPS) in immigrant groups using native Swedish-born individuals as referents. This is a retrospective study. The study population included all individuals aged 18 years and older registered in Sweden. PPS was defined as having at least one registered diagnosis in the Swedish National Patient Register. The incidence of post-polio in different immigrant groups, using Swedish-born individuals as referents, was assessed by Cox regression, with hazard ratios (HRs) and 99% confidence intervals (CI). The models were stratified by sex and adjusted for age, geographical residence in Sweden, educational level, marital status, co-morbidities, and neighbourhood socioeconomic status. In total 5300 post-polio cases were registered, 2413 males and 2887 females. Fully adjusted HRs (99% CI) in immigrants versus Swedish-born were 1.77 in men (1.52-2.07) and 1.39 (1.19-1.62) in women. Statistically significant excess risks of post-polio were found in the following subgroups: men and women from Africa, HRs (with 99% CI) 7.40 (5.17-10.59) and 8.39 (5.44-12.95), respectively, and Asia, HRs 6.32 (5.11-7.81) and 4.36 (3.38-5.62) respectively, and in men from Latin America, HR 3.66 (2.17-6.18). It is of importance to be aware of risks of PPS in immigrants settled in Western countries, and that it is more common in immigrants from regions of the world where polio is still prevalent. Patients with PPS need treatment and proper follow-up until polio has been eradicated through global vaccination programs.

摘要

为了研究使用原籍瑞典出生的个体作为参照人群时移民群体患后发小儿麻痹症综合征(PPS)的风险。这是一项回顾性研究。研究人群包括所有在瑞典登记的年龄在 18 岁及以上的个体。在瑞典国家患者登记处至少有一个登记诊断即可定义为 PPS。使用原籍瑞典出生的个体作为参照人群,通过 Cox 回归评估不同移民群体的 post-polio 发生率,并用风险比(HR)和 99%置信区间(CI)表示。这些模型按性别分层,并根据年龄、在瑞典的地理位置、教育程度、婚姻状况、合并症和邻里社会经济地位进行调整。共登记了 5300 例 post-polio 病例,男性 2413 例,女性 2887 例。在男性和女性中,移民与原籍瑞典出生者相比,完全调整后的 HR(99%CI)分别为 1.77(1.52-2.07)和 1.39(1.19-1.62)。在以下亚组中发现 post-polio 的风险显著增加:来自非洲的男性和女性,HR(99%CI)分别为 7.40(5.17-10.59)和 8.39(5.44-12.95),以及来自亚洲的男性和女性,HR 分别为 6.32(5.11-7.81)和 4.36(3.38-5.62),来自拉丁美洲的男性 HR 为 3.66(2.17-6.18)。了解在西方国家定居的移民患 PPS 的风险很重要,而且在那些小儿麻痹症仍流行的世界地区的移民中更为常见。患有 PPS 的患者需要治疗和适当的随访,直到通过全球疫苗接种计划根除小儿麻痹症。

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本文引用的文献

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Narcolepsy among first- and second-generation immigrants in Sweden: A study of the total population.
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