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and health outcomes: An overview of systematic reviews and meta-analyses.

作者信息

Li Zhongyu, Wang Yang, Xu Qing, Ma Jinxin, Li Xuan, Yan Jiaxing, Tian Yibing, Wen Yandong, Chen Ting

机构信息

Department of Gastroenterology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

Department of Chinese Medicine, Eye Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

出版信息

Front Nutr. 2023 Mar 28;10:1107750. doi: 10.3389/fnut.2023.1107750. eCollection 2023.


DOI:10.3389/fnut.2023.1107750
PMID:37057067
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10086143/
Abstract

BACKGROUND: () consumption has been associated with various health outcomes; however, the results are not completely consistent. OBJECTIVES: This overview of systematic reviews and meta-analyses aimed to evaluate the reporting and methodological quality, and to grade the available evidence of associations between and health outcomes. METHODS: PubMed, Cochrane Library, Embase, and Scopus databases were searched from their inception to September 30, 2022. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2009 statement, Assessment of Multiple Systematic Reviews (AMSTAR) 2 checklist, and Grades of Recommendations, Assessment, Development and Evaluations (GRADE) systems were used to assess the reporting, methodological, and evidence quality for each meta-analysis, respectively. The results were synthesized in a narrative form. RESULTS: This overview included 20 eligible meta-analyses published in peer-reviewed journals between 2013 and 2021. The overall methodological quality was relatively poor, with only one moderate quality, four low quality, and 15 critically low quality studies. For reporting quality, items two, five, eight, nine, 15, and 24 need to improve. Among the 110 outcome indicators of the quality of evidence, five were graded as moderate, 17 as low, and 88 as very low. Risk of bias, inconsistency, and imprecision were the main downgrading factors. CONCLUSION: This overview suggests that is beneficial for various clinical outcomes. However, there are certain limitations to reporting and methodological quality. The clinical efficacy of requires confirmation in high-quality, large-sample, randomized controlled trials.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ef4/10086143/4aa18e115397/fnut-10-1107750-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ef4/10086143/b00802b0d689/fnut-10-1107750-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ef4/10086143/2b8238604712/fnut-10-1107750-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ef4/10086143/4aa18e115397/fnut-10-1107750-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ef4/10086143/b00802b0d689/fnut-10-1107750-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ef4/10086143/2b8238604712/fnut-10-1107750-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ef4/10086143/4aa18e115397/fnut-10-1107750-g0003.jpg

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[7]
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[8]
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[10]
In vitro potential antiviral SARS-CoV-19- activity of natural product thymohydroquinone and dithymoquinone from Nigella sativa.

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