Kmail Abdalsalam, Said Omar, Saad Bashar
Faculty of Sciences, Arab American University, Jenin P.O. Box 240, Palestine.
Beleaf Pharma, Kfar Kana 16930, Israel.
Curr Issues Mol Biol. 2023 Nov 13;45(11):9039-9059. doi: 10.3390/cimb45110567.
Wound healing is a multifaceted process necessitating the collaboration of numerous elements to mend damaged tissue. Plant and animal-derived natural compounds have been utilized for wound treatment over the centuries, with many scientific investigations examining these compounds. Those with antioxidant, anti-inflammatory, and antibacterial properties are particularly noteworthy, as they target various wound-healing stages to expedite recovery. Thymoquinone, derived from ()-a medicinal herb with a long history of use in traditional medicine systems such as Unani, Ayurveda, Chinese, and Greco-Arabic and Islamic medicine-has demonstrated a range of therapeutic properties. Thymoquinone exhibits antimicrobial, anti-inflammatory, and antineoplastic activities, positioning it as a potential remedy for skin pathologies. This review examines recent research on how thymoquinone accelerates wound healing and the mechanisms behind its effectiveness. We carried out a comprehensive review of literature and electronic databases, including Google Scholar, PubMed, Science Direct, and MedlinePlus. Our aim was to gather relevant papers published between 2015 and August 2023. The main criteria for inclusion were that the articles had to be peer reviewed, original, written in English, and discuss the wound-healing parameters of thymoquinone in wound repair. Our review focused on the effects of thymoquinone on the cellular and molecular mechanisms involved in wound healing. We also examined the role of cytokines, signal transduction cascades, and clinical trials. We found sufficient evidence to support the effectiveness of thymoquinone in promoting wound healing. However, there is no consensus on the most effective concentrations of these substances. It is therefore essential to determine the optimal treatment doses and the best route of administration. Further research is also needed to investigate potential side effects and the performance of thymoquinone in clinical trials.
伤口愈合是一个多方面的过程，需要众多因素协同作用来修复受损组织。几个世纪以来，植物和动物来源的天然化合物一直被用于伤口治疗，许多科学研究都在探究这些化合物。具有抗氧化、抗炎和抗菌特性的化合物尤其值得关注，因为它们针对伤口愈合的各个阶段以加速恢复。百里醌，源自（）——一种在尤纳尼、阿育吠陀、中医以及希腊 - 阿拉伯和伊斯兰医学等传统医学体系中有着悠久使用历史的药用植物——已展现出一系列治疗特性。百里醌具有抗菌、抗炎和抗肿瘤活性，使其成为皮肤病症的一种潜在治疗方法。本综述考察了近期关于百里醌如何加速伤口愈合及其有效性背后机制的研究。我们对包括谷歌学术、PubMed、科学Direct和MedlinePlus在内的文献和电子数据库进行了全面综述。我们的目的是收集2015年至2023年8月期间发表的相关论文。纳入的主要标准是文章必须经过同行评审、原创、用英文撰写，并且讨论百里醌在伤口修复中的伤口愈合参数。我们的综述聚焦于百里醌对伤口愈合所涉及的细胞和分子机制的影响。我们还研究了细胞因子、信号转导级联反应以及临床试验的作用。我们发现有充分证据支持百里醌在促进伤口愈合方面的有效性。然而，对于这些物质的最有效浓度尚无共识。因此，确定最佳治疗剂量和最佳给药途径至关重要。还需要进一步研究来调查潜在的副作用以及百里醌在临床试验中的表现。
