Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Halal Research Center of IRI, Food and Drug Administration, Ministry of Health and Medical Education, Tehran, Iran.
Crit Rev Food Sci Nutr. 2024;64(4):943-956. doi: 10.1080/10408398.2022.2110566. Epub 2022 Aug 17.
This study was performed to assess the effect of nigella supplementation on blood pressure levels among the adult population. A comprehensive search was carried out through PubMed, Scopus, Web of Science, and Cochrane Library by using relevant keywords to find out the randomized clinical trials evaluating the effect of nigella administration on systolic blood pressure (SBP) and diastolic blood pressure (DBP). A random-effect model was applied to achieve the overall effect size. Subgroup analysis and meta-regression were used to explore the source of heterogeneity and the effects of the possible moderators. Of the twenty-two trials that were eligible for the present study, seventeen studies consisting of 1048 participants were included in the meta-analysis. The results indicated that nigella administration could significantly reduce both SBP (-4.58 mmHg; 95%CI: -6.22, -2.94) and DBP (-3.08 mmHg; 95%CI: -4.62, -1.55). Subgroup analysis did not show any superiority between subgroups of variables. Dose-response analysis detected a nonlinear association between dose and duration of administration and change in blood pressure outcomes, highlighting that maximum SBP and DBP reduction was experienced at 2000 mg/day and 8 weeks of nigella administration, respectively. The present study suggests that nigella supplementation can be beneficial for managing blood pressure.
这项研究旨在评估黑种草补充剂对成年人群血压水平的影响。通过使用相关关键词，在 PubMed、Scopus、Web of Science 和 Cochrane Library 进行了全面检索，以找出评估黑种草给药对收缩压（SBP）和舒张压（DBP）影响的随机临床试验。应用随机效应模型得出总体效应大小。亚组分析和荟萃回归用于探索异质性的来源和可能的调节因素的影响。在符合本研究条件的二十二项试验中，有十七项研究（包含 1048 名参与者）被纳入荟萃分析。结果表明，黑种草给药可显著降低收缩压（-4.58mmHg；95%CI：-6.22，-2.94）和舒张压（-3.08mmHg；95%CI：-4.62，-1.55）。亚组分析未显示出变量亚组之间的优越性。剂量反应分析检测到剂量和给药持续时间与血压变化结果之间存在非线性关联，这表明在 2000mg/天和 8 周的黑种草给药时，最大的收缩压和舒张压降低分别被观察到。本研究表明，黑种草补充剂可能有益于控制血压。
