间充质干细胞免疫调节：机制与治疗潜力。
Mesenchymal Stem Cell Immunomodulation: Mechanisms and Therapeutic Potential.
机构信息
Center for Stem Cell Therapeutics and Imaging (CSTI), Harvard Medical School, Boston, MA 02115, USA; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Medical Oncology, the First Hospital of China Medical University, Shenyang 110001, China.
Center for Stem Cell Therapeutics and Imaging (CSTI), Harvard Medical School, Boston, MA 02115, USA; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
出版信息
Trends Pharmacol Sci. 2020 Sep;41(9):653-664. doi: 10.1016/j.tips.2020.06.009. Epub 2020 Jul 22.
Mesenchymal stem/stromal cells (MSCs) are multipotent cells that are emerging as the most promising means of allogeneic cell therapy. MSCs have inherent immunomodulatory characteristics, trophic activity, high invitro self-renewal ability, and can be readily engineered to enhance their immunomodulatory functions. MSCs affect the functions of most immune effector cells via direct contact with immune cells and local microenvironmental factors. Previous studies have confirmed that the immunomodulatory effects of MSCs are mainly communicated via MSC-secreted cytokines; however, apoptotic and metabolically inactivated MSCs have more recently been shown to possess immunomodulatory potential, in which regulatory T cells and monocytes play a key role. We review the immunomodulatory aspects of naïve and engineered MSCs, and discuss strategies for increasing the potential of successfully using MSCs in clinical settings.
间充质干细胞（MSCs）是多能细胞，它们作为同种异体细胞治疗的最有前途的手段而出现。MSCs 具有固有免疫调节特性、营养活性、高体外自我更新能力，并且可以很容易地被工程化以增强其免疫调节功能。MSCs 通过与免疫细胞和局部微环境因素的直接接触来影响大多数免疫效应细胞的功能。先前的研究已经证实，MSC 的免疫调节作用主要通过 MSC 分泌的细胞因子进行通讯；然而，最近已经表明凋亡和代谢失活的 MSC 具有免疫调节潜能，其中调节性 T 细胞和单核细胞起着关键作用。我们综述了幼稚 MSC 和工程 MSC 的免疫调节方面，并讨论了增加成功将 MSC 用于临床环境中的潜力的策略。
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