Fan Dianfa, Liu Xiyu, Shen Zhen, Wu Pan, Zhong Liping, Lin Faquan
State Key Laboratory of Targeting Oncology, National Center for International Research of Bio-targeting Theranostics, Guangxi Key Laboratory of Bio-targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Bio-targeting Theranostics, Guangxi Medical University, Nanning, Guangxi 530021, China.
State Key Laboratory of Targeting Oncology, National Center for International Research of Bio-targeting Theranostics, Guangxi Key Laboratory of Bio-targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Bio-targeting Theranostics, Guangxi Medical University, Nanning, Guangxi 530021, China.
Biomed Pharmacother. 2023 Jun;162:114695. doi: 10.1016/j.biopha.2023.114695. Epub 2023 Apr 13.
Vitamin C, a small organic molecule, is widely found in fruits and vegetables and is an essential nutrient in the human body. Vitamin C is closely associated with some human diseases such as cancer. Many studies have shown that high doses of vitamin C have anti-tumor ability and can target tumor cells in multiple targets. This review will describe vitamin C absorption and its function in cancer treatment. We will review the cellular signaling pathways associated with vitamin C against tumors depending on the different anti-cancer mechanisms. Based on this, we will further describe some applications of the use of vitamin C for cancer treatment in preclinical and clinical trials and the possible adverse events that can occur. Finally, this review also assesses the prospective advantages of vitamin C in oncology treatment and clinical applications.
维生素C是一种小分子有机化合物，广泛存在于水果和蔬菜中，是人体必需的营养素。维生素C与某些人类疾病如癌症密切相关。许多研究表明，高剂量的维生素C具有抗肿瘤能力，可在多个靶点靶向肿瘤细胞。本综述将描述维生素C的吸收及其在癌症治疗中的作用。我们将根据不同的抗癌机制，综述与维生素C抗肿瘤相关的细胞信号通路。在此基础上，我们将进一步描述维生素C在临床前和临床试验中用于癌症治疗的一些应用以及可能发生的不良事件。最后，本综述还评估了维生素C在肿瘤治疗和临床应用中的潜在优势。
