University of Southern California, Suzanne Dworak-Peck School of Social Work, Los Angeles, CA, USA.
University of Southern California, Keck School of Medicine, Department of Psychiatry and Behavioral Sciences, Los Angeles, CA, USA.
Contemp Clin Trials. 2023 Jun;129:107181. doi: 10.1016/j.cct.2023.107181. Epub 2023 Apr 12.
Post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) are highly prevalent, and co-occurring among post-9/11 veterans. Mobile health (mHealth) applications, specifically those focused on mindfulness-based techniques, may be an effective avenue to intervene with veterans who cannot or will not seek care at traditional in-person settings. Thus, to address areas of improvement in mHealth for veterans, we developed Mind Guide and prepared it for testing in a pilot randomized controlled trial (RCT) with veterans.
We have completed phase 1 (treatment development) and Phase 2 (beta test) of our mobile mHealth app, Mind Guide. In this paper we describe the methods for Phase 1 as well as results for our beta test (n = 16; inclusion criteria included screen for PTSD, AUD, a post-9/11 veteran, and not currently receiving treatment) for Mind Guide as well as outline procedures for our pilot RCT of Mind Guide (Phase 3). The PTSD Checklist, self-reported alcohol use, the Perceived Stress Scale, Penn Alcohol Craving Scale, and the Emotion Regulation Questionnaire were used.
Results of our beta test of Mind Guide show promising past 30 day effects on PTSD (d = -1.12), frequency of alcohol use (d = -0.54), and alcohol problems (d = -0.44), and related mechanisms of craving (d = -0.53), perceived stress (d = -0.88), and emotion regulation (d = -1.22).
Our initial beta-test of Mind Guide shows promise for reducing PTSD and alcohol related problems among veterans. Recruitment is ongoing for our pilot RCT in which 200 veterans will be recruited and followed up for 3 months.
gov Identifier: NCT04769986.
创伤后应激障碍（PTSD）和酒精使用障碍（AUD）在 9/11 后退伍军人中普遍存在且常同时发生。移动健康（mHealth）应用程序，特别是那些专注于正念技术的应用程序，可能是一种有效的干预手段，适用于那些无法或不愿在传统面对面环境中寻求治疗的退伍军人。因此，为了改善退伍军人的 mHealth 服务，我们开发了 Mind Guide，并准备在一项针对退伍军人的试点随机对照试验（RCT）中进行测试。
我们已经完成了移动 mHealth 应用程序 Mind Guide 的第 1 阶段（治疗开发）和第 2 阶段（测试版）。在本文中，我们描述了第 1 阶段的方法，以及对 Mind Guide 的测试版（n = 16；纳入标准包括 PTSD、AUD、9/11 后退伍军人和目前未接受治疗的筛查）的结果，并概述了 Mind Guide 试点 RCT 的程序（第 3 阶段）。使用了 PTSD 检查表、自我报告的酒精使用情况、感知压力量表、宾夕法尼亚酒精渴望量表和情绪调节问卷。
Mind Guide 测试版的结果显示，过去 30 天对 PTSD（d = -1.12）、饮酒频率（d = -0.54）和酒精问题（d = -0.44）以及相关的渴望机制（d = -0.53）、感知压力（d = -0.88）和情绪调节（d = -1.22）有积极影响。
我们对 Mind Guide 的初步测试显示，它有望减少退伍军人的 PTSD 和与酒精相关的问题。我们正在招募 200 名退伍军人进行试点 RCT，他们将被随访 3 个月。
gov 标识符：NCT04769986。
